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Showing 1–4 of 4 results
Advanced filters: Author: Myrthala Moreno-Smith Clear advanced filters

  • Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.

    • Ling Tao
    • Mahmoud A. Mohammad
    • Eveline Barbieri
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growth

    • Myrthala Moreno-Smith
    • Giorgio Milazzo
    • Eveline Barbieri
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • The microRNA-200 family members have a role in regulating tumour angiogenesis but the underlying mechanism is unclear. In this study, Pecot et al.demonstrate that miR-200 affects angiogenesis by altering endothelial and cancer cell cytokine secretion.

    • Chad V. Pecot
    • Rajesha Rupaimoole
    • Anil K. Sood
    Research
    Nature Communications
    Volume: 4, P: 1-14