The V1-V2 loops of the HIV envelope protein play an important role in HIV vaccine development. Here, Rahman et al. demonstrate in macaques that the efficacy of V1-deleted envelope vaccines, abrogated by oral delivery of control nanoparticles, is rescued by nanoparticles carrying V2 scaffold peptide strengthening the mucosal V2-specific response.
- Mohammad Arif Rahman
- Massimiliano Bissa
- Jay A. Berzofsky
