Coeliac disease is an immune-mediated enteropathy induced by gluten. Generation of gluten-specific CD4+ T cells is necessary but not sufficient to induce overt disease. Now, epithelial stress has been proposed as a distinct factor that synergizes with the anti-gluten adaptive immune response to induce intraepithelial lymphocyte activation and tissue damage.
- Nadine Cerf-Bensussan
- Bertrand Meresse
