Nature Search

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Efficacy of faricimab secondary to anti-vascular endothelial growth factor agents in patients with neovascular age-related macular degeneration: a systematic review and meta-analysis

Eric Jin
Adrian CY Chan
George N. Thomas
Reviews20 Aug 2025
Eye

Volume: 39, P: 2738-2751
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Anubha Mahajan
Cassandra N. Spracklen
Andrew P. Morris
Research12 May 2022
Nature Genetics

Volume: 54, P: 560-572
Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes

Evgeny I. Rogaev
Ekaterina A. Rogaeva
Peter H. St George-Hyslop
Research01 Oct 1993
Nature Genetics

Volume: 5, P: 158-162
Ecosystem Functioning

J. N. BLACK
Books & Arts14 Sept 1968
Nature

Volume: 219, P: 1188-1189
A catalog of genetic loci associated with kidney function from analyses of a million individuals

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Matthias Wuttke
Yong Li
Cristian Pattaro
Research31 May 2019
Nature Genetics

Volume: 51, P: 957-972
Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-cell lung cancer

M Ando
K Eguchi
N Saijo
Research01 Dec 1997
British Journal of Cancer

Volume: 76, P: 1494-1499
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

Krzysztof Kiryluk
Elena Sanchez-Rodriguez
Ali G. Gharavi
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1091-1105
23-Gauge transconjunctival sutureless pars plana vitrectomy: results of a prospective study

C Schweitzer
M-N Delyfer
J-F Korobelnik
Research23 Jan 2009
Eye

Volume: 23, P: 2206-2214
Has allogeneic stem cell cryopreservation been given the ‘cold shoulder’? An analysis of the pros and cons of using frozen versus fresh stem cell products in allogeneic stem cell transplantation

N V Frey
H M Lazarus
S C Goldstein
Reviews07 Aug 2006
Bone Marrow Transplantation

Volume: 38, P: 399-405
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Trans-ethnic analyses of exome array data identify new risk loci for type 2 diabetes. Fine-mapping analyses using genome-wide association data show that the index coding variants represent the likely causal variants at only a subset of these loci.

Anubha Mahajan
Jennifer Wessel
Mark I. McCarthy
Research09 Apr 2018
Nature Genetics

Volume: 50, P: 559-571
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

Adrienne Tin
Jonathan Marten
Anna Köttgen
Research02 Oct 2019
Nature Genetics

Volume: 51, P: 1459-1474
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.

Yingchang Lu
Felix R. Day
Ruth J. F. Loos
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-15
Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma

There is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functional validation in preclinical models.

Daniel Schäfer
Stefan Tomiuk
Olaf Hardt
ResearchOpen Access05 Mar 2021
Nature Communications

Volume: 12, P: 1-18
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.

Alexander Teumer
Layal Chaker
Marco Medici
ResearchOpen Access26 Oct 2018
Nature Communications

Volume: 9, P: 1-14
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

Salt intake is associated with hypertension, but the mechanisms by which salt affects blood pressure remain unclear. Agnes Machnik et al. now show that mononuclear cells such as macrophages respond to dietary salt intake by producing the growth factor VEGF-C, leading to expansion of the lymphatic capillary network. Interference with this response in rats fed a high-salt diet exacerbates the increase in blood pressure caused by a high-salt dietpages 487–488..

Agnes Machnik
Wolfgang Neuhofer
Jens Titze
Research03 May 2009
Nature Medicine

Volume: 15, P: 545-552
A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence

Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.

Reliza J. McGinnis
Chad A. Brambley
Jamie R. Wallen
ResearchOpen Access14 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Thyroid and Adrenal Dysfunction in Abstinent Alcoholic Men: Locus of Disturbance

Peter T. Loosen
Bryan Chambliss
David N. Orth
Research01 Dec 1993
Neuropsychopharmacology

Volume: 9, P: 255-266
Dose-finding study of irinotecan and cisplatin plus concurrent radiotherapy for unresectable stage III non-small-cell lung cancer

A Yokoyama
Y Kurita
T Matsuda
Research01 Jul 1998
British Journal of Cancer

Volume: 78, P: 257-262
MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination

Meiotic recombination enables reciprocal exchange of genetic material between paternal and maternal homologous chromosomes. Here Luo et al.show that MEIOB, a novel meiosis-specific factor identified in a proteomics screen, forms complexes with RPA2 and SPATA22, and is required for meiotic recombination.

Mengcheng Luo
Fang Yang
P. Jeremy Wang
Research18 Nov 2013
Nature Communications

Volume: 4, P: 1-12
A multidisciplinary study unveils the nature of a Roman ink of the I century AD

Mirta Sibilia
Chiaramaria Stani
Federica Gonzato
ResearchOpen Access31 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
Space-borne Bose–Einstein condensation for precision interferometry

A Bose–Einstein condensate is created in space that has sufficient stability to enable its characteristic dynamics to be studied.

Dennis Becker
Maike D. Lachmann
Ernst M. Rasel
Research17 Oct 2018
Nature

Volume: 562, P: 391-395
In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022

HL McLeod
VG Brunton
MA Graham
Research01 Dec 1996
British Journal of Cancer

Volume: 74, P: 1714-1718
Novel strategies for the treatment of small-cell lung carcinoma

Small-cell lung cancer has a poor prognosis and treatment options for this disease are limited. The authors discuss the molecular biology and current clinical management of progressive small-cell lung cancer, and critically evaluate the recent SPEAR trial, in which the use of second-line picoplatin was investigated.

William N. William Jr
Bonnie S. Glisson
Reviews21 Jun 2011
Nature Reviews Clinical Oncology

Volume: 8, P: 611-619
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

The self-renewal of mouse embryonic stem cells is enhanced by inhibiting glycogen synthase kinase-3 (Gsk3). β-catenin is now found to be necessary for this effect through its interaction with Tcf3 to abrogate its repressive action for the expression of genes from the core pluripotency network.

Jason Wray
Tüzer Kalkan
Austin Smith
Research19 Jun 2011
Nature Cell Biology

Volume: 13, P: 838-845
Fetal Erythropoietin Levels in Growth-Restricted and Appropriately Grown Neonates With and Without Abnormal Fetal Heart Rate Tracings: A Comparison With Cord Blood Gases and Apgar Scores

Allahyar Jazayeri
John C M Tsibris
William N Spellacy
Research09 Dec 1999
Journal of Perinatology

Volume: 19, P: 255-259
Fractionated administration of irinotecan and cisplatin for treatment of non-small-cell lung cancer: a phase II study of Okayama Lung Cancer Study Group

H Ueoka
M Tanimoto
M Harada
ResearchOpen Access03 Jul 2001
British Journal of Cancer

Volume: 85, P: 9-13
Docetaxel (Taxotere^TM) in advanced gastric cancer: results of a phase II clinical trial. EORTC Early Clinical Trials Group

A Sulkes
J Smyth
J Verweij
Research01 Aug 1994
British Journal of Cancer

Volume: 70, P: 380-383
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.

Thomas W. Winkler
Humaira Rasheed
Iris M. Heid
ResearchOpen Access13 Jun 2022
Communications Biology

Volume: 5, P: 1-20
An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

Matthew L Cooper
Jaebok Choi
John F DiPersio
Research20 Feb 2018
Leukemia

Volume: 32, P: 1970-1983
Second-line pazopanib in patients with relapsed and refractory small-cell lung cancer: a multicentre phase II study of the Hellenic Oncology Research Group

F Koinis
S Agelaki
A Kotsakis
ResearchOpen Access16 May 2017
British Journal of Cancer

Volume: 117, P: 8-14
A late phase II study of RP56976 (docetaxel) in patients with advanced or recurrent breast cancer

I Adachi
T Watanabe
T Taguchi
Research01 Jan 1996
British Journal of Cancer

Volume: 73, P: 210-216
A multicentre phase II study of docetaxel 75 mg m-2 as first-line chemotherapy for patients with advanced breast cancer: report of the Clinical Screening Group of the EORTC

V Dieras
B Chevallier
P Fumoleau
Research01 Aug 1996
British Journal of Cancer

Volume: 74, P: 650-656
Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O₂^.− upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells

M-U-D Lone
K S Baghel
S Bhadauria
Research10 Oct 2016
Oncogene

Volume: 36, P: 1829-1839
AMPA Receptor Potentiation can Prevent Ethanol-Induced Intoxication

Nicholas Jones
Marcus J Messenger
Steve C R Williams
Research12 Sept 2007
Neuropsychopharmacology

Volume: 33, P: 1713-1723
Embryonic lethality and defective male germ cell development in mice lacking UTF1

Seth D. Kasowitz
Mengcheng Luo
P. Jeremy Wang
ResearchOpen Access08 Dec 2017
Scientific Reports

Volume: 7, P: 1-10
Incorporation of Eu(III) into Calcite under Recrystallization conditions

S. E. Hellebrandt
S. Hofmann
M. Schmidt
ResearchOpen Access15 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Perinatal factors, growth and development, and osteosarcoma risk

R Troisi
M N Masters
R N Hoover
ResearchOpen Access14 Nov 2006
British Journal of Cancer

Volume: 95, P: 1603-1607
The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation

J Zhu
C Zhao
K Dahlman-Wright
ResearchOpen Access20 Jan 2014
Oncogene

Volume: 33, P: 4340-4351
Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial

J Cassidy
J-Y Douillard
L P Garrison
ResearchOpen Access18 Apr 2006
British Journal of Cancer

Volume: 94, P: 1122-1129

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