Targeting splenic macrophages with immunosuppressive microRNA is a potential therapeutic strategy for sepsis. Interference of splenic macrophages by miR-146a-expressing plasmid and polyethyleneimine complex modulates the Toll-like receptor-related immunity, which results in the amelioration of excessive inflammation, multiple organ injury, and even death due to sepsis.
- Yoshio Funahashi
- Noritoshi Kato
- Kenji Kadomatsu
