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The efficacy of CAR-T cells against solid tumors is still limited by immunosuppressive factors. Here, the authors show that engineering of CAR T cells with A1R enhances their efficacy against solid tumors in vitro and in vivo.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

Electron spins generated by phosphorus dopant atoms buried in silicon represent well-isolated quantum bits with long coherence times, but so far the control of such single electrons has been insufficient to use them in this way. These authors report single-shot, time-resolved readout of electron spins in silicon, achieved by coupling the donor atoms to a charge-sensing device called a single-electron transistor. This opens a path to the development of a new generation of quantum computing and spintronic devices in silicon.

A single electron spin in silicon is dressed by a microwave field to create a new qubit with tangible advantages for quantum computation and nanoscale research.

A large nuclear spin has been successfully placed in a Schrödinger cat state, a superposition of its two most widely separated spin coherent states. This can be used as an error-correctable qubit.

Qudits, higher-dimensional analogues of qubits, expand quantum state space for information processing using fewer physical units. Here the authors demonstrate control over a 16-dimensional Hilbert space, equivalent to four qubits, using combined electron-nuclear states of a single Sb donor atom in Si.

Donors spins in silicon are coherent, high-performance qubits, but scale-up has been challenging. Here the authors present the first experimental demonstration of exchange-based, entangling two qubit gates between electrons bound to ³¹P donors in Si.

The coherent operation of individual ³¹P electron and nuclear spin qubits in a ²⁸Si substrate shows new benchmark decoherence times and provides essential information on the dechorence mechanism.

Operating donor-based quantum computers in silicon is hindered by the dependence of inter-qubit coupling on the precise donor position. Here, the authors show controlled rotation operation on exchange-coupled electron spins in the weak-exchange regime, loosening the requirements on positioning precision.

Phase-resolved mid-infrared observations from JWST of the hot gas giant WASP-43b detect a day–night difference of 659 ± 19 K. Comparison with climate models shows that the observations are compatible with cloudy skies, at least on the nightside, and the lack of methane detection suggests the presence of disequilibrium chemistry.

The transmission spectrum of the exoplanet WASP-39b is obtained using observations from the Single-Object Slitless Spectroscopy mode of the Near Infrared Imager and Slitless Spectrograph instrument aboard the JWST.

Universal quantum logic operations with fidelity exceeding 99%, approaching the threshold of fault tolerance, are realized in a scalable silicon device comprising an electron and two phosphorus nuclei, and a fidelity of 92.5% is obtained for a three-qubit entangled state.

Time-series observations from the JWST of the transiting exoplanet WASP-39b show gaseous water in the planet’s atmosphere and place an upper limit on the abundance of methane.

Observations from the JWST MIRI/LRS show the detection of SO₂ spectral features in the 5–12-μm transmission spectrum of the hot, Saturn-mass exoplanet WASP-39b, suggesting that photochemistry is a key process in high-temperature exoplanet atmospheres.

The presence of multiple minima, or valleys, in the conduction band of group IV semiconductors can be a problem for spin-based quantum computing, but can also enable alternative qubit implementations. Yang et al. demonstrate electrostatic control of the valleys’ energy splitting in a silicon quantum dot.

Electrical detection and coherent manipulation of a single ³¹P nuclear spin qubit is reported; the high fidelities are promising for fault-tolerant nuclear-spin-based quantum computing using silicon.

A combined analysis of datasets across four JWST instrument modes provides a benchmark transmission spectrum for the Saturn-mass WASP-39 b. The broad wavelength range and high resolution constrain orbital and stellar parameters to below 1%.

The LHCb collaboration reports an improved measurement of the oscillation frequency of mesons consisting of a bottom quark and strange quark, which is then combined with previous results.

The existence and properties of tetraquark states with two heavy quarks and two light antiquarks have been widely debated. Here, the authors use a unitarized model to study the properties of an exotic narrow state compatible with a doubly charmed tetraquark.

The Large Hadron Collider beauty collaboration reports a test of lepton flavour universality in decays of bottom mesons into strange mesons and a charged lepton pair, finding evidence of a violation of this principle postulated in the standard model.

A broad-wavelength 0.5–5.5 µm atmospheric transmission spectrum of WASP-39b, a 1,200 K, roughly Saturn-mass, Jupiter-radius exoplanet, demonstrates JWST’s sensitivity to a rich diversity of exoplanet compositions and chemical processes.

A violation of Bell's inequality, which is a direct proof of entanglement, can be observed in the solid state using the electron and nuclear spins of a single phosphorus atom in silicon.

The coherent manipulation of an individual electron spin qubit bound to a single phosphorus donor atom in natural silicon provides an excellent platform on which to build a scalable quantum computer.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

The discovery of a long-period radio transient, GPM J1839–10, prompted a search of radio archives, thereby finding that this source has been repeating since at least 1988.

Osteogenesis imperfecta, or 'brittle bone disease', is a clinically heterogeneous heritable connective tissue disorder, the causative defects of which are directly related to type I collagen. Human cases and murine models of osteogenesis imperfecta are providing insight into common pathways in dominant and recessive osteogenesis imperfecta, leading to the re-evaluation of its definition, classification and therapeutic approaches.

The accurate determination of quark mixing parameters is essential for the understanding of the Standard Model. The LHCb collaboration now reports the coupling strength of the b quark to the u quark through the measurement of a baryonic decay mode.

CP violation has deep implications for particle physics and cosmology. Previously observed only in meson decays, signs of CP violation have now been spotted in baryon decays by analysing the proton–proton collision data from the LHCb detector.

The LHCb Collaboration reports the observation of an exotic, narrow, tetraquark state that contains two charm quarks, an up antiquark and a down antiquark.

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

The electron spin in a silicon-based quantum dot can be controlled electrically for as long as several tens of microseconds, which improves the prospects for quantum information processing based on this type of quantum dot.