Dysfunction of SUMO or Rad60 causes overlapping phenotypes that include genomic instability. Now, a nonsubstrate interaction between SUMO-like domain 2 (SLD2) of Rad60 and the SUMO-conjugating enzyme Ubc9 is shown to suppress aberrant replication-associated homologous recombination. Thus, SUMO mimicry provides critical regulation in the SUMO pathway.
- John Prudden
- J Jefferson P Perry
- Michael N Boddy