Using single-cell/single-nucleus RNA sequencing and spatial transcriptomic analysis, Calcagno and Taghdiri et al. define the ischemic border zone—the area between the poorly perfused infarct area and the remote zones of the heart—based on the cardiomyocyte transcriptomes. The transcriptional border zone emerges within an hour of the ischemic injury and can be observed in response to any injury that causes loss of neighboring cells and mechanical destabilization, including the trauma induced with a fine needle.
- D. M. Calcagno
- N. Taghdiri
- K. R. King
