The CTCF/cohesin complex regulates higher order chromatin structure by creating long-range chromatin loops and by insulating neighboring genes from each other. The lymphocyte antigen receptor loci have large numbers of CTCF/cohesin binding sites, and recent studies demonstrate that the CTCF/cohesin complex plays several important roles in regulating the process of V(D)J recombination at these megabase-sized receptor loci.
- Ann J Feeney
- Jiyoti Verma-Gaur
