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Lab-based surveillance of Shigella has traditionally been based on serotyping but increasing availability of whole genome sequencing could enable higher resolution typing. Here, the authors apply a core genome multilocus sequence typing scheme to Shigella sequence data and describe its population structure.

The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify emergence of distinct subpopulations of NEPC cells.

FUT10 and FUT11, originally annotated as α1,3-fucosyltransferases, are actually protein O-fucosyltransferases participating in a non-canonical ER quality control pathway for EMI domain-containing protein secretion.

CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV.

The efficacy of epidural electrical stimulation (EES) to engage arm muscles and improve movement after spinal cord injury is still unclear. Here, the authors investigated how EES can recruit upper-limb motor neurons by combining computational modelling with experiments in non-human primates.

Prescribed burning is a common tool to mitigate the risk of dangerous wildfires. However, careful consideration of the public health impacts should be incorporated into forest management plans.

Chiral photons can accelerate the differentiation of neural stem cells into neurons in vitro and in vivo when DNA-bridged chiral assemblies of gold nanoparticles are tightly entangled with the cells’ cytoskeletal fibres.

Hole and particle-like quasiparticles of a Mott insulator can pair into excitonic bound states. Now, time-resolved measurements of Sr₂IrO₄ show signs of an excitonic fluid forming from a photo-excited population of quasiparticles.

BACH2 is required for lymphocyte differentiation. Afzali et al. describe mutations that cause BACH2 disruption, immunodeficiency and autoinflammatory disease via haploinsufficiency, a mechanism shared by other super-enhancer-regulated genes.

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options. Here they show that adeno-associated virus mediated gene therapy prevents disease progression in a mouse disease model.

Atomistic simulations have a broad range of applications from drug design to materials discovery. Machine learning interatomic potentials (MLIPs) have become an efficient alternative to computationally expensive ab initio simulations. Now a general reactive MLIP (called ANI-1xnr) has been developed and validated against a broad range of condensed-phase reactive systems.

A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

Despite their relevance for quantum technology, photon-pair sources are difficult to control. A theoretical proposal shows how photon pairs can be created from vacuum fluctuations in time-dependent systems, potentially enabling heralded single-photon frequency combs.

Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

Identification of tissue proteoforms by top-down mass spectrometry remains challenging. Here, the authors present AutoPiMS, a semi-automated multiplexed tandem mass spectrometry workflow for proteoform identification directly from tissue contexts.

Mucus are ubiquitous natural materials, but little is known about their structures or properties. Here, the authors identify the components of three functional mucus from snails, which are the focus of a rapidly growing number of biomedical and cosmetic applications.

Single-cell whole-genome sequencing shows that 'foreground' cell-to-cell structural variation and alterations in copy number are associated with genomic diversity and evolution in triple-negative breast and high-grade serous ovarian cancers.

Macroscopic stretching can convert achiral nanoparticle composites into chiral materials whose optical properties can be reversibly modulated.

The Prigogine–Defay ratio quantifies how many parameters are needed to fully characterize the glass-transition behaviour of a viscous liquid. For a single parameter, this ratio is unity, but it has never been clear whether any real liquid has such a value. A discovery of a connection between this ratio and the density scaling behaviour of silicone oil suggests it does.

Submillimetre surveys have discovered a population of luminous, high-redshift, dusty starburst galaxies, which go through a phase of very rapid star formation, resulting in approximately equal extragalactic optical and far infrared backgrounds (FIRB). Devlin et al. report an extragalactic survey at 250, 350 and 500 µm; they determine that all of the FIRB comes from individual galaxies, with galaxies at redshift z ≥ 1.2 accounting for 70 per cent of it.

Optical near-field microscopy has facilitated our understanding of nanophotonics. This Perspective explores the opportunities that near-field studies of terahertz fields provide for ultrafast phase transitions in condensed matter systems.

Understanding the role of coherent structures in the dynamics of turbulent flows is of high relevance for fluid dynamics, climate systems, and aerodynamics. The authors propose a deep learning approach to evaluate the importance of various types of coherent structure in the flow, to uncover main mechanisms of wall-bounded turbulence and develop techniques for its control.

The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

A study of hospitalized patients infected with SARS-CoV-2 and who have liquid or solid cancer suggests that hematologic malignancy is an independent risk factor for mortality and that CD8⁺ T cells might limit infection in this setting irrespective of humoral immunity.

Human development provides a roadmap for advancing pluripotent stem cell-based regenerative therapies. Here the authors mapped human skeletogenesis using RNA sequencing on 5 cell types from a single foetal stage as well as chondrocytes at 4 stages in vivo and 2 stages during in vitro differentiation.

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Nicholas Croucher and colleagues report whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae, a major cause of pneumonia, bacteremia and meningitis. They examine the impact of the introduction of the pneumococcal conjugate vaccine PCV7 on pneumococcal population dynamics.

brainlife.io is a one-stop cloud platform for data management, visualization and analysis in human neuroscience. It is web-based and provides access to a variety of tools in a reproducible and reliable manner.

A reduction in the strength of the Atlantic Meridional Overturning Circulation initiated during the penultimate deglaciation led to excess polar ice losses, contributing to higher sea levels during the last interglacial period.

Lauer and colleagues examine CD8⁺ T cells following cure of human hepatitis C virus (HCV) infection. CD8⁺ T cells exposed to chronic HCV-specific activation show durable functional, phenotypic and transcriptional exhaustion that is maintained even after antigen stimulus is removed.

Causality has fundamentally restricted perfect sound absorption and radiation. This work shows how engineered instability can bypass these constraints, enabling near-perfect acoustic blackbody behavior through a universal theoretical framework validated across different physical implementations.