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Showing 1–2 of 2 results
Advanced filters: Author: Naadiya Carrim Clear advanced filters

  • Immune thrombocytopenia (ITP) is caused by autoantibody-mediated platelet clearance, but refractoriness to current immunomodulatory therapies is common. Here the authors show that desialylated platelets can be cleared via hepatic Ashwell–Morell receptor, a process that can be attenuated by sialidase inhibitors, suggesting a new therapy for ITP.

    • June Li
    • Dianne E. van der Wal
    • Heyu Ni
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-16

  • Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis.

    • Xiaohong Ruby Xu
    • Yiming Wang
    • Heyu Ni
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18