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Showing 1–3 of 3 results
Advanced filters: Author: Nader Ghasemlou Clear advanced filters

  • Melanoma cells interact with pain-mediating sensory neurons by increasing their release of the neuropeptide CGRP, which increases the exhaustion of CD8+ T cells and thus promotes the survival of cancer cells.

    • Mohammad Balood
    • Maryam Ahmadi
    • Sebastien Talbot
    ResearchOpen Access
    Nature
    Volume: 611, P: 405-412

  • This study shows that most known mediators of immunity, such as TLR2, MyD88, T cells or B cells, and neutrophils and monocytes, are dispensable for pain produced by Staphylococcus aureus infection; instead, bacterial products, such as N-formylated peptides and α-haemolysin, induce pain by directly activating nociceptor neurons, which in turn modulate inflammation.

    • Isaac M. Chiu
    • Balthasar A. Heesters
    • Clifford J. Woolf
    Research
    Nature
    Volume: 501, P: 52-57