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Showing 1–3 of 3 results
Advanced filters: Author: Nagaraja Muniappa Clear advanced filters

  • A panel of urinary biomarkers enables the progression of renal injury and subsequent repair and recovery to be monitored after exposure of rats to either carbapenem A or gentamicin. The authors complement this study by demonstrating that serum cystatin C is more sensitive and specific than serum creatinine and blood urea nitrogen in monitoring generalized renal function after exposure to nephrotoxicants.

    • Josef S Ozer
    • Frank Dieterle
    • David L Gerhold
    Research
    Nature Biotechnology
    Volume: 28, P: 486-494

  • Exposure of rats to kidney toxicants reduces levels of urinary trefoil factor 3 (TFF3) and increases levels of urinary albumin. Whereas urinary albumin outperforms either serum creatinine (SCr) or blood urea nitrogen (BUN) for detecting kidney tubule damage, urinary TFF3 abundance complements the capacity of combined SCr and BUN levels to detect renal injury.

    • Yan Yu
    • Hong Jin
    • David L Gerhold
    Research
    Nature Biotechnology
    Volume: 28, P: 470-477

  • Urinary kidney injury-1 (Kim-1) outperforms serum creatinine, blood urea nitrogen and urinary N-acetyl-β-D-glucosaminidase in detecting kidney damage induced in rats by a range of nephrotoxicants. Earlier detection of renal injury, enabled by monitoring levels of urinary Kim-1, should enable elimination of nephrotoxic candidates sooner in the drug development pipeline.

    • Vishal S Vaidya
    • Josef S Ozer
    • Joseph V Bonventre
    Research
    Nature Biotechnology
    Volume: 28, P: 478-485