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Showing 1–4 of 4 results
Advanced filters: Author: Naiara Santana-Codina Clear advanced filters

  • Pharmacologic inhibition of dihydroorotate dehydrogenase (DHODH) shows limited efficacy in pancreatic ductal adenocarcinoma (PDAC) models. Here the authors find that targeting the anti-apoptotic protein BCL-XL synergizes with DHODH inhibition in promoting apoptosis in PDAC cells, patient-derived organoids, and PDAC mouse models.

    • Huan Zhang
    • Naiara Santana-Codina
    • Joseph D. Mancias
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Twelve early career investigators share experiences from the process of starting their laboratories throughout the past year, and reflect on the challenges faced and the opportunities seized.

    • Mautin Barry-Hundeyin
    • Jian Carrot-Zhang
    • Ying Zhang
    Reviews
    Nature Cancer
    Volume: 3, P: 1426-1431

  • Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose phosphate pathway gene RPIA and that targeting nucleotide metabolism restore sensitivity to KRAS pathway inhibition.

    • Naiara Santana-Codina
    • Anjali A. Roeth
    • Alec C. Kimmelman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13