Nature Search

In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice

Human intestinal organoids are endowed with immune cells by transplantation into humanized mice.

Carine Bouffi
Kathryn A. Wikenheiser-Brokamp
Michael A. Helmrath
ResearchOpen Access26 Jan 2023
Nature Biotechnology

Volume: 41, P: 824-831
RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis

Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD) arises from mutations in Angiotensin II sensing genes, but how they impact the kidney was unclear. This study reveals that delayed angiogenesis at a critical developmental window underlies AR-RTD.

Naomi Pode-Shakked
Megan Slack
Raphael Kopan
ResearchOpen Access09 Dec 2023
Nature Communications

Volume: 14, P: 1-18
Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport

Enteroendocrine cells (EECs) are specialized gastrointestinal cells that have a role in nutrient sensing and hormone secretion. Here the authors show that peptide YY from EECs regulates nutrient absorption in intestinal organoids.

Heather A. McCauley
Andrea L. Matthis
James M. Wells
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-10
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

Organoids formed by combining pluripotent-stem-cell-derived human neural crest cells with pluripotent-stem-cell-derived intestinal tissue show functional interstitial cells of Cajal and undergo waves of contraction; these tissues reveal insights into the molecular defects characterizing Hirschsprung's disease.

Michael J Workman
Maxime M Mahe
James M Wells
Research21 Nov 2016
Nature Medicine

Volume: 23, P: 49-59
An in vivo model of human small intestine using pluripotent stem cells

An in vivo model of the human small intestine is established in mice using human pluripotent stem cells.

Carey L Watson
Maxime M Mahe
Michael A Helmrath
Research19 Oct 2014
Nature Medicine

Volume: 20, P: 1310-1314
CSF-1 activates MAPK-dependent and p53-independent pathways to induce growth arrest of hormone-dependent human breast cancer cells

Angel Wai-mun Lee
Sundaram Nambirajan
John G Moffat
Research09 Dec 1999
Oncogene

Volume: 18, P: 7477-7494

Quick links

Search

Filter By:

In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice

RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis

Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

An in vivo model of human small intestine using pluripotent stem cells

CSF-1 activates MAPK-dependent and p53-independent pathways to induce growth arrest of hormone-dependent human breast cancer cells

Search

Quick links