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The instability of perovskites with exsolved nanoparticles for CO₂ electrocatalysis impedes their practical applications. Here, the authors show the formation of B-site vacancies in perovskite substrate as a major contributor to the degradation and report a strategy to enhance the stability of the perovskites at high voltages.

Glypican-1 (GPC1) expression is elevated in pancreatic cancer and has been exploited as a therapeutic target. Here the authors report the development of V_HH nanobody-based CAR-T cells targeting GPC1, showing anti-tumor activity in pancreatic cancer preclinical models.

In metals, dendrite orientation during crystal growth has been hypothesized to be affected by compositional additions. Here, the authors combine molecular dynamics and experiments in the aluminium-samarium system to prove solute atoms can affect dendrite orientation via interfacial energy changes.

Using a monolayer molecular crystal as a seeding layer, hafnium oxide dielectrics with an equivalent oxide thickness of only 1 nm can be deposited on graphene, molybdenum disulfide and tungsten diselenide.

Here, the authors devise a synthesis strategy to optimize the stability and thermoelectric performance of Cu₂Se-based materials. They obtain a maximum ZT value of ~2.82 at 1000 K on Cu₂Se-BiCuSeO-graphene composites.

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

Solid oxide ionic conductors typically require elevated temperature to activate ionic transport. Here the authors report unusually high proton conductivity close to room temperature in a hydrogenated oxide, HSrCoO_2.5, which they attribute to the intrinsically ordered oxygen vacancy channels and high proton concentration.

Metabolism changes can modulate immune responses in many contexts, and vice versa. Here the authors associate metabolomic, as well as cytokine and chemokine, data from stratified COVID-19 patients to find that arginine, tryptophan and purine metabolic pathways correlate with hyperproliferation, thus hinting at potential therapeutic targets for severe COVID-19 patients.

Quantum repeaters are critical components for distributing entanglement over long distances, and they can be improved by the elimination of multi-photon-pair events. Here, the authors demonstrate the storage of single photons emitted by a quantum dot in a polarization maintaining solid-state memory.

High-precision photoemission measurements determine that the superconducting pairing symmetry in KFe₂As₂ is the same as in other types of iron-based superconductors, despite having different features in the band structure.

Polar spirals induced in a relaxor ferroelectric can be quasi-continuously rotated by applying electric/mechanical fields, due to an asymmetric Coulomb interaction. The rotations are non-volatile with robust retention, and can be optically read out.

Unlike Panax species, which can produce dammarane-type saponins, Aralia elata can only synthesize oleananetype saponins. Here, the authors reveal that the loss of the dammaranediol synthase-encoding gene and tandem duplication of triterpene biosynthetic genes drive structural divergences of saponins between the two genera.

Rice false smut, caused by the pathogenic ascomycete fungus Ustilaginoidea virens (Cooke) Takah, has a significant economic impact on crop production. Here, Zhang et al. report the draft genome sequence of U. virensand provide insight into the evolution of genes involved in pathogenicity and adaptation to a biotrophic and floret-infecting lifestyle.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

How excitatory neurons (EN) acquire senescence is unclear. Here, the authors show that GDF11 in ENs slows EN senescence, brain ageing, cognitive decline and maintains lifespan, revealing a mechanism underlying EN senescence and brain ageing.

Polymer dielectric capacitors are important for energy storage, although they often suffer from low energy density, especially at high temperatures, and challenges in mass production. This study reports roll-to-roll fabricated composites enriched with subnanosheet fillers, showcasing enhanced performance even at elevated temperatures.

A workflow integrating tools from bioinformatics, structural biology and synthetic biology has been developed that enables the rapid design of pili-enabled living materials. This approach allows mining of pili-producing nonpathogenic chassis, understanding of the pili structure and assembly, and engineering of pili-enabled living materials in a systematic and sequential manner.

Chen et al. provide an m⁵C landscape in bladder cancer and show m⁵C enrichment at oncogene mRNAs that promotes tumour progression. They identify YBX1 as the m⁵C ‘reader’ that recruits ELAVL1 to stabilize mRNAs.

Functional interaction between an aquaporin and a membrane-tethered growth suppressor MYB transcription factor leads to activation of the latter, establishing a link between hydraulics and transcriptional control.

Reconfigurable electronic devices that can be shaped in two or more stable geometries modifying their functionalities have been realized by engineering the sequence in which the elastomeric substrates are mechanically buckled.

A common failure of many cancer treatments is attributed to the resistance imparted by tumour hypoxia. Here, the authors report on the generic synthesis of small-sized hollow mesoporous organosilica nanoparticles which are designed for oxygen-independent X-ray-activated synergistic therapy.

Electron beam lithography (EBL) is renowned to provide fabrication resolution in the deep nanometer scale but their incapability of arbitrary 3D nanofabrication poses a major limitation to the technique. Here, the authors demonstrate a manufacturing technique of functional 3d nanostructures at a resolution of sub-15 nm using voltage-regulated 3d EBL.

A new donkey reference genome and comparisons with wild asses yields insights into the evolutionary history of donkey domestication and identifies a genetic variant that results in the non-Dun coat colours of domestic donkeys.

Different types of mesenchymal progenitors participate in ectopic bone formation. Here, the authors show Col2⁺ lineage cells adopt a lymphatic endothelium cell fate, which regulates local inflammatory microenvironment after trauma, thus influencing heterotopic ossification (HO) development via a FGFR3-BMPR1a pathway.

The development of heterogeneous photocatalysts applicable under harsh conditions is challenging. Here the authors report the conversion of imine linkages into quinoline groups in triphenylamine incorporated photosensitive covalent organic frameworks to develop robust heterogeneous photocatalysts for photocatalytic applications in harsh conditions.

The orphan GPR84 plays important roles in inflammation, fibrosis, and metabolism. Here, authors report cryo-EM structures of the receptor bound to two ligands, with insights into ligand binding and entry from the extracellular milieu.

The common approaches to control of skymions cause significant heat dissipation or require high electric fields near the breakdown threshold. Here, the authors demonstrate electric-field control of skyrmions through strain-mediated magnetoelectric coupling in multiferroic heterostructures.

There is an urgent need to develop effective heterogeneous Fenton-like catalysts for water treatment. Here, the authors demonstrate that nanoconfinement of cobalt oxide catalysts in carbon nanotubes can selectively degrade pollutants at high reaction rate.

Here, using population-based modeling on ensemble Hi-C data, the authors provide an expansive overview of how the genic chromatin microenvironment influences its potential involvement in different functions, such as transcription, DNA replication, and chromatin compartmentalization. Their results unveil a key role of nuclear speckles in genome organization.

High-energy-density lithium metal batteries suffer from limited cycle life. Here the authors develop a homogeneous and mechanically stable solid–electrolyte interphase by using a trioxane-modulated electrolyte, thereby expanding battery cyclability.

Invasion of the gut by oral bacteria in liver cirrhosis.

Microglia and monocytes contribute to neuropathic pain states, but the precise role of the two cell types is not clear. Here Peng et al.use temporally controlled ablation of monocytes and microglia in mice to show that these cells work together to initiate neuropathic-pain like behaviour, but are less important in the maintenance phase.

USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Liet al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and breast cancer development.

Patients with liver diseases are at increased risk of fungal infections. Here the authors show that Kupffer cells are critical for the filtration of fungi out of the blood and thereby for liver-mediated protection against disseminating fungal infection.