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SARS-CoV-2 infection establishes a stable and age-independent CD8⁺ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

Although SARS-CoV2 epitope characterization has been the focus of extensive research, these efforts have largely focused on the spike protein. Here, the authors demonstrate that CD8⁺ T cell responses can be directed against a dominant nucleocapsid epitope and rely on a highly focused T cell receptor repertoire.

Cecily Choy
Joseph Chen
Nan-Ping Weng
ResearchOpen Access23 Oct 2023
Nature Communications

Volume: 14, P: 1-19
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

Here, the authors discuss what is known about the gene expression and chromatin modifications in memory T cells that make these cells distinct from naive T cells, and provide some opinions on the future direction of the field.

Nan-ping Weng
Yasuto Araki
Kalpana Subedi
Reviews16 Mar 2012
Nature Reviews Immunology

Volume: 12, P: 306-315
Erratum: Themis, a T cell–specific protein important for late thymocyte development

Renaud Lesourne
Shoji Uehara
Paul E Love
Amendments and Corrections01 Jan 2010
Nature Immunology

Volume: 11, P: 97
Heterogeneity and transcriptome changes of human CD8⁺ T cells across nine decades of life

The characterisation of T cells during aging is important to predict functional outcomes in vaccination or infection. Here the authors use flow cytometry and scRNA sequencing to transcriptionally age CD8 T cells and then use a machine learning model to interpret cell age from transcriptional profiles.

Jian Lu
Raheel Ahmad
Nan-ping Weng
ResearchOpen Access01 Sept 2022
Nature Communications

Volume: 13, P: 1-13
Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire

For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 of the pre-selection antigen receptors are essential for the selection of MHC-restricted repertoire.

Jinghua Lu
François Van Laethem
Peter D. Sun
ResearchOpen Access04 Mar 2019
Nature Communications

Volume: 10, P: 1-14
Themis, a T cell–specific protein important for late thymocyte development

The molecular mechanisms that underpin thymocyte selection remain incompletely defined. Groups led by Love, Gascoigne and Schwartz independently identify Themis, a signaling protein essential for the positive selection of thymocytes.

Renaud Lesourne
Shoji Uehara
Paul E Love
Research13 Jul 2009
Nature Immunology

Volume: 10, P: 840-847
Telomeres in T and B cells

Richard J. Hodes
Karen S. Hathcock
Nan-ping Weng
Reviews01 Sept 2002
Nature Reviews Immunology

Volume: 2, P: 699-706
Analyzing the phenotypic and functional complexity of lymphocytes using CyTOF (cytometry by time-of-flight)

Guobing Chen
Nan-ping Weng
Research Highlights28 May 2012
Cellular & Molecular Immunology

Volume: 9, P: 322-323

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