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Showing 1–4 of 4 results
Advanced filters: Author: Nancie A. Mooney Clear advanced filters

  • The CPLANE complex is essential for ciliogenesis, and mutations to all but one subunit have been associated with ciliopathies. Here they identify three familial mutations in the final subunit, RSG1, that cause ciliopathy and add to our understanding of ciliary transition zone assembly.

    • Neftalí Vazquez
    • Chanjae Lee
    • John B. Wallingford
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The understudied lipid kinase PIP4K2C binds SARS-CoV-2 nonstructural protein 6 and regulates virus-induced autophagic flux impairment, suppressing viral protein degradation. PIP4K2C inhibition is a candidate strategy to combat emerging viruses.

    • Marwah Karim
    • Manjari Mishra
    • Shirit Einav
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18