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Scientific Reports (3)
International Journal of Obesity (1)
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Showing 1–6 of 6 results

Advanced filters: Author: Nancie J. MacIver Clear advanced filters

Irgm1 regulates metabolism and function in T cell subsets

Yazan Alwarawrah
Keiko Danzaki
Nancie J. MacIver
ResearchOpen Access17 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression

T cells undergo metabolic reprogramming after they are activated. Rathmell and colleagues show that inflammatory Toll-like receptor signals induce glycolysis and impair the suppression of regulatory T cells, but Foxp3 can promote a switch to oxidative phosphorylation and suppression.

Valerie A Gerriets
Rigel J Kishton
Jeffrey C Rathmell
Research03 Oct 2016
Nature Immunology

Volume: 17, P: 1459-1466
Emerging mechanisms of obesity-associated immune dysfunction

In this Review, the emerging cellular and molecular mechanisms by which obesity impairs key aspects of immunity are discussed, including changes in the abundance of key hormones, dysregulation of adipose-tissue-derived extracellular vesicles and dysregulation of polyunsaturated fatty acid metabolism.

Saame Raza Shaikh
Melinda A. Beck
Nancie J. MacIver
Reviews21 Dec 2023
Nature Reviews Endocrinology

Volume: 20, P: 136-148
Insulin and IGF-1 have both overlapping and distinct effects on CD4⁺ T cell mitochondria, metabolism, and function

Kaitlin Kiernan
Yazan Alwarawrah
Nancie J. MacIver
ResearchOpen Access21 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity

Yazan Alwarawrah
Amanda G. Nichols
Nancie J. MacIver
Research09 Oct 2020
International Journal of Obesity

Volume: 44, P: 2419-2429
Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness

Brian J. Andonian
Alec Koss
Kim M. Huffman
ResearchOpen Access06 May 2022
Scientific Reports

Volume: 12, P: 1-13