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Showing 1–5 of 5 results
Advanced filters: Author: Nancy Schultz-Darken Clear advanced filters

  • Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.

    • Dawn M. Dudley
    • Matthew T. Aliota
    • David H. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.

    • Christina M. Newman
    • Dawn M. Dudley
    • Thomas C. Friedrich
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

    • Dawn M. Dudley
    • Christina M. Newman
    • Matthew T. Aliota
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Glycerol monolaurate in a microbicide is shown to protect monkeys from infection after intra-vaginal exposure to high doses of SIV. The suppressive activity may be due to the inhibition of target cell recruitment due to glycerol-monolaurate-mediated inhibition of epithelial cell signalling and inflammatory cytokine expression.

    • Qingsheng Li
    • Jacob D. Estes
    • Ashley T. Haase
    Research
    Nature
    Volume: 458, P: 1034-1038