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Showing 1–2 of 2 results
Advanced filters: Author: Nanditha Anandakrishnan Clear advanced filters
  • The authors previously reported HCK was associated with kidney inflammation and fibrosis. Here, they further unravel a mechanism of HCK regulating autophagy within macrophages, altering their polarization, proliferation, and migration and they also developed a more selective HCK inhibitor.

    • Man Chen
    • Madhav C. Menon
    • Chengguo Wei
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • The drug development pipeline for kidney diseases is plagued with challenges ranging from an insufficient understanding of disease mechanisms to a lack of robust preclinical models. Bioengineering approaches have the potential to streamline preclinical drug discovery efforts and improve the success of clinical trials for kidney disease.

    • Nanditha Anandakrishnan
    • Evren U. Azeloglu
    Comments & Opinion
    Nature Reviews Nephrology
    Volume: 16, P: 623-624