Nature Search

IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia

Additional roles of metabolic enzymes in cancer remain to be explored. Here, the authors show nuclear localized PYCR1 undergoes IGF1R-mediated phosphorylation under hypoxia, binds with ELK4 and recruits SIRT7 to modulate transcription of target genes to promote colorectal cancer progression.

Ke Zheng
Nannan Sha
Tao Chen
ResearchOpen Access30 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Laser-induced reconfigurable wavefront control with a structured Ge₂Sb₂Te₅-based metasurface

A tunable metasurface exhibiting dynamically optical functionalities is highly desired in practice. Here, the authors demonstrate a dynamically reconfigurable metasurface by combining the Ge₂Sb₂Te₅-rod array with laser engineering technology, for which various optical functionalities can be randomly and reversibly written and erased.

Sha Hu
Chao Wang
Changzhi Gu
ResearchOpen Access25 Oct 2024
Communications Physics

Volume: 7, P: 1-6
RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth

The authors identify genes potentially involved in NAD(H) redox modulation and provide insight on major hit HES4, which uses its transcriptional repressive function to drive pyrimidine nucleotide biosynthesis and tumor growth.

Jing He
Aoxue Wang
Yuhui Jiang
Research20 May 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1413-1425
The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress

Ma et al. find that PHGDH, which catalyses serine metabolism in the cytoplasm, transits to the nucleus during nutrient stress, where it promotes cell growth and tumorigenesis.

Chunmin Ma
Ke Zheng
Yuhui Jiang
Research18 Oct 2021
Nature Metabolism

Volume: 3, P: 1357-1371
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation

Nannan Sha
Bei Zhou
Qin Zhao
Research26 Jan 2025
Oncogene

Volume: 44, P: 1078-1092
The underlying mechanisms of DNA methylation in high salt memory in hypertensive vascular disease

Nannan Liu
Yixiao Chen
Lina Xia
ResearchOpen Access09 Jan 2024
Scientific Reports

Volume: 14, P: 1-14
GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation

Shupei Wei
Qin Zhao
Nanshan Zhong
ResearchOpen Access09 Aug 2022
Cell Discovery

Volume: 8, P: 1-16
Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis

Yao Chen
Yuxuan Zheng
Ming-Han Tong
ResearchOpen Access30 Jul 2018
Cell Research

Volume: 28, P: 879-896
Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers

Pin Wang
Lei Wang
Xiaoping Zou
ResearchOpen Access07 Jun 2017
Scientific Reports

Volume: 7, P: 1-9

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IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia

Laser-induced reconfigurable wavefront control with a structured Ge₂Sb₂Te₅-based metasurface

RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth

The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress

The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation

The underlying mechanisms of DNA methylation in high salt memory in hypertensive vascular disease

GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation

Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis

Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers

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