Fucoidan is a sulfated glycan with anticoagulant properties, but its structural complexity and heterogeneity hinders understanding of its structure-activity relationship. Here, the authors synthesize a diverse library of 58 distinct fucoidans with multiple contiguous 1,2-cis glycosidic bonds and various sulfation patterns, and investigate their anticoagulant activity.
- Si-Cong Chen
- Xianjin Qin
- Xin-Shan Ye
