Nature Search

Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
CT-based phenotyping of COVID-19: cluster analysis of pulmonary and extrapulmonary imaging markers from a multicentre retrospective cohort study

Shiro Otake
Naoya Tanabe
Koichi Fukunaga
ResearchOpen Access26 Nov 2025
Scientific Reports

Volume: 15, P: 1-13
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control

Motoshi Iwao
Ryota Tanaka
Hiroki Itoh
ResearchOpen Access09 Nov 2021
Scientific Reports

Volume: 11, P: 1-9
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Dispersion state of carbon black in polystyrene produced with different dispersion media and its effects on composite rheological properties

The dispersion state and aggregate structure of carbon black in polystyrene composites prepared by solvent casting suspensions in different dispersion media with different particle contents and their effects on the bulk rheological properties of the composites were investigated by transmission electron microscopy, ultrasmall-angle and small-angle X-ray scattering, and dynamic viscoelasticity measurements. The viscoelastic moduli of the melt polymer composites below and above the percolation limit varied with the dispersion medium, reflecting the difference in the macroscopic dispersion state and aggregate structure of carbon black in polystyrene.

Yudai Fukunaga
Yoshihisa Fujii
Naoya Torikai
Research16 Nov 2018
Polymer Journal

Volume: 51, P: 275-281
High-Density Lipoprotein Cholesterol and Insulin Resistance Are Independent and Additive Markers of Left Ventricular Hypertrophy in Essential Hypertension

Futoshi Anan
Hidetoshi Yonemochi
Hironobu Yoshimatsu
Research01 Feb 2007
Hypertension Research

Volume: 30, P: 125-131
Postchallenge Plasma Glucose and Glycemic Spikes Are Associated with Pulse Pressure in Patients with Impaired Glucose Tolerance and Essential Hypertension

Futoshi Anan
Takayuki Masaki
Hironobu Yoshimatsu
Research01 Aug 2008
Hypertension Research

Volume: 31, P: 1565-1571
Urinary podocyte mRNAs precede microalbuminuria as a progression risk marker in human type 2 diabetic nephropathy

Akihiro Fukuda
Akihiro Minakawa
Shouichi Fujimoto
ResearchOpen Access23 Oct 2020
Scientific Reports

Volume: 10, P: 1-11

Search

Host control of persistent Epstein–Barr virus infection

CT-based phenotyping of COVID-19: cluster analysis of pulmonary and extrapulmonary imaging markers from a multicentre retrospective cohort study

DOCK2 is involved in the host genetics and biology of severe COVID-19

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Blood DNA virome associates with autoimmune diseases and COVID-19

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control

Mapping the human genetic architecture of COVID-19

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

A second update on mapping the human genetic architecture of COVID-19

Dispersion state of carbon black in polystyrene produced with different dispersion media and its effects on composite rheological properties

High-Density Lipoprotein Cholesterol and Insulin Resistance Are Independent and Additive Markers of Left Ventricular Hypertrophy in Essential Hypertension

Postchallenge Plasma Glucose and Glycemic Spikes Are Associated with Pulse Pressure in Patients with Impaired Glucose Tolerance and Essential Hypertension

Urinary podocyte mRNAs precede microalbuminuria as a progression risk marker in human type 2 diabetic nephropathy

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