The Slit2 receptor Robo4 is known to maintain vascular permeability. Robo 4 prevents the formation of endothelial cell protrusions through a complex with paxillin and Arf–GAPs, which inhibits the GTPase Arf6a and thus leads to Rac activation.
- Christopher A. Jones
- Naoyuki Nishiya
- Dean Y. Li