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Showing 1–4 of 4 results
Advanced filters: Author: Nasreen Ismail Clear advanced filters

  • Despite antiretroviral therapy, HIV often persists in tissue sanctuary sites. In this work, authors investigate HIV persistence and T cell responses in lymph node biopsies obtained from individuals who initiated antiretroviral therapy in Fiebig stage I and beyond.

    • Omolara O. Baiyegunhi
    • Jaclyn Mann
    • Zaza M. Ndhlovu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • l-cysteine is required for the growth of Lactobacillus iners, a vaginal microbiome species typically associated with adverse outcomes that lacks cysteine biosynthesis pathways and key uptake mechanisms present in other lactobacilli. Cystine uptake inhibitors can be used to suppress L. iners abundance in vitro in favour of L. crispatus, a species associated with favourable outcomes.

    • Seth M. Bloom
    • Nomfuneko A. Mafunda
    • Douglas S. Kwon
    Research
    Nature Microbiology
    Volume: 7, P: 434-450

  • Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely related protective and less protective HLA alleles, and their differential effect on viral control

    • Funsho Ogunshola
    • Gursev Anmole
    • Zaza M Ndhlovu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14