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Showing 1–6 of 6 results
Advanced filters: Author: Nastasja Kreim Clear advanced filters

  • The E3 ligase Hakai can interact with the m6A methylation machinery but its function is still unclear. Here, the authors show that Hakai is a conserved component of the m6A methyltransferase complex and provide functional and molecular insights into its role in regulating m6A levels in Drosophila.

    • Praveen Bawankar
    • Tina Lence
    • Jean-Yves Roignant
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Transcription can pose a threat to genomic instability through the formation of R-loops, which are RNA–DNA hybrids with a displaced non-template DNA strand. Here the authors mapped the R-loop proximal proteome in human cells and identified a role of the tumor suppressor DDX41 in opposing R-loop and double strand DNA break accumulation in gene promoters.

    • Thorsten Mosler
    • Francesca Conte
    • Petra Beli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The exon junction complex (EJC) has been identified as functioning as a post-transcriptional gene regulator. Here the authors reveal that the complex also plays a part in the regulation of transcription by regulating the release of Pol II pausing into transcription elongation.

    • Junaid Akhtar
    • Nastasja Kreim
    • Jean-Yves Roignant
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.

    • Marina E. Borisova
    • Andrea Voigt
    • Petra Beli
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • One of the most abundant modifications found in messenger RNAs is N6-methyladenosine (m6A); here, this modification is shown to alter gene expression during sex determination and affect neuronal functions and behaviour in Drosophila via the m6A reader protein YT521-B.

    • Tina Lence
    • Junaid Akhtar
    • Jean-Yves Roignant
    Research
    Nature
    Volume: 540, P: 242-247