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Showing 1–2 of 2 results
Advanced filters: Author: Nathalie Rion Clear advanced filters

  • Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injury

    • Perrine Castets
    • Nathalie Rion
    • Markus A. Rüegg
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Long non-coding RNAs (lncRNAs) belong to the ever-increasing number of transcripts that are thought not to encode proteins. A recent study has now identified a small polypeptide encoded by the lncRNA LINC00961 that inhibits amino acid-induced mTORC1 activation in skeletal muscle.

    • Nathalie Rion
    • Markus A Rüegg
    Research Highlights
    Cell Research
    Volume: 27, P: 604-605