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Gpcpd1–GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism

Cikes et al. report dysregulation of glycerophosphocholine (GPC) metabolism in aged mouse muscle, which they functionally link to severe glucose intolerance. Correspondingly, muscle GPC levels are altered in both older adults and patients with type 2 diabetes.

Domagoj Cikes
Michael Leutner
Josef M. Penninger
Research18 Jan 2024
Nature Aging

Volume: 4, P: 80-94
Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin

Laurie Frances
Mikaël Croyal
Nathalie Viguerie
ResearchOpen Access15 Mar 2024
International Journal of Obesity

Volume: 48, P: 973-980
Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

Deletion of the transcription factor Irf5 in macrophages leads to expansion of the subcutaneous fat depot but restriction of the visceral fat during obesity, resulting in improved insulin sensitivity

Elise Dalmas
Amine Toubal
Nicolas Venteclef
Research04 May 2015
Nature Medicine

Volume: 21, P: 610-618
Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

A Besse-Patin
E Montastier
N Viguerie
Research27 Aug 2013
International Journal of Obesity

Volume: 38, P: 707-713
An integrated single cell and spatial transcriptomic map of human white adipose tissue

Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human datasets to provide a comprehensive cellular map of white adipose tissue.

Lucas Massier
Jutta Jalkanen
Niklas Mejhert
ResearchOpen Access15 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1

Peter Arner
Nathalie Viguerie
Daniel Peter Andersson
ResearchOpen Access15 Mar 2024
International Journal of Obesity

Volume: 48, P: 934-940
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for Bayesian fine-mapping and functional assessment in flies.

Armand Valsesia
Qiao-Ping Wang
Jörg Hager
ResearchOpen Access01 Feb 2019
Nature Communications

Volume: 10, P: 1-10
Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity

Impaired adipocyte insulin signalling characterizes insulin resistance. Here the authors show that the hormone-sensitive lipase can sequester the glucose-responsive transcription factor ChREBP in the cytoplasm, which prevents transcription of its target ELOVL6, resulting in reduced insulin signalling.

Pauline Morigny
Marianne Houssier
Dominique Langin
Research03 Dec 2018
Nature Metabolism

Volume: 1, P: 133-146
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.

Jérôme Carayol
Christian Chabert
Jörg Hager
ResearchOpen Access12 Dec 2017
Nature Communications

Volume: 8, P: 1-14
Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes

Emilie Montastier
Diane Beuzelin
Nathalie Viguerie
Research27 Nov 2018
International Journal of Obesity

Volume: 43, P: 1485-1490
Common mouse models of chronic kidney disease are not associated with cachexia

Chronic kidney disease (CKD) includes loss of renal function combined with numerous other health complications. An investigation of CKD-associated complication of cachexia in mouse models highlights that the time-course of renal failure and muscle wasting are not causal in these models.

Benjamin Lair
Marlène Lac
Cedric Moro
ResearchOpen Access20 Mar 2024
Communications Biology

Volume: 7, P: 1-11
FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression

Shannon L. Klingel
Armand Valsesia
David M. Mutch
Research06 Aug 2018
International Journal of Obesity

Volume: 43, P: 1539-1548
Integrative phenotyping of glycemic responders upon clinical weight loss using multi-omics

Armand Valsesia
Anirikh Chakrabarti
Mojgan Masoodi
ResearchOpen Access08 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes

Marine Coué
Valentin Barquissau
Cedric Moro
ResearchOpen Access18 Jan 2018
Scientific Reports

Volume: 8, P: 1-12

Search

Gpcpd1–GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism

Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity

Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes

Common mouse models of chronic kidney disease are not associated with cachexia

FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression

Integrative phenotyping of glycemic responders upon clinical weight loss using multi-omics

Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes

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