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Showing 1–3 of 3 results
Advanced filters: Author: Nathan Hardenbrook Clear advanced filters
  • IP6 is a critical host cofactor for HIV-1 assembly and infectivity. In this study, the authors uncover the structural basis by which HIV-1 adapts to a deficiency in IP6 packaging through a G225R mutation at the C-terminus of the capsid protein.

    • Yanan Zhu
    • Alex B. Kleinpeter
    • Peijun Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • The bacterial translocase channel anthrax toxin is composed of the protective antigen (PA) that forms a translocase channel and two cytotoxic enzymes: lethal factor (LF) and edema factor (EF), which go through the PA channel to enter host cells. Here the authors provide mechanistic insights into LF and EF translocation by determining the cryo-EM structures of the anthrax toxin transmembrane channel protein in complex with LF and EF.

    • Nathan J. Hardenbrook
    • Shiheng Liu
    • Bryan A. Krantz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10