Nature Search

Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease

Coufal and colleagues generated microglia from human iPS cells to examine mechanistic roles of the transcription factor MEF2C and how these roles might relate to the autism phenotype seen following the loss of MEF2C in human microglia.

Celina Nguyen
Emily H. Broersma
Nicole G. Coufal
ResearchOpen Access22 Oct 2025
Nature Immunology

Volume: 26, P: 1989-2003
Sterols and oxysterols in immune cell function

Sterols and oxysterol derivatives of cholesterol regulate diverse cellular processes. Nathanael Spann and Christopher Glass review the emerging data indicating that these endogenous compounds also serve key roles in almost all aspects of immunological function.

Nathanael J Spann
Christopher K Glass
Reviews20 Aug 2013
Nature Immunology

Volume: 14, P: 893-900
Genetic variation in the activity of a TREM2–p53 signaling axis determines oxygen-induced lung injury

Sajti and colleagues identify TREM2 as a critical factor in myeloid cells in response to hyperoxia-induced lung injury in neonates, finding that TREM2 deficiency protects mice from bronchopulmonary dysplasia.

Yohei Abe
Nathanael J. Spann
Eniko Sajti
Research25 Jul 2025
Nature Immunology

Volume: 26, P: 1287-1298
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes

The mechanisms by which noncoding genetic variation shapes tissue macrophage phenotypic diversity remain obscure. Glass and colleagues define cell-intrinsic and environmental effects contributing to genetic control of Kupffer cell transcription.

Hunter Bennett
Ty D. Troutman
Christopher K. Glass
ResearchOpen Access21 Sept 2023
Nature Immunology

Volume: 24, P: 1825-1838
Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.

Gregory J. Fonseca
Jenhan Tao
Christopher K. Glass
ResearchOpen Access24 Jan 2019
Nature Communications

Volume: 10, P: 1-16
Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

Sympathetic neuron–associated macrophages act as a local sink for norepinephrine, leading to reduced thermogenesis and increased obesity.

Roksana M Pirzgalska
Elsa Seixas
Ana I Domingos
Research09 Oct 2017
Nature Medicine

Volume: 23, P: 1309-1318
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity

Glass and colleagues show that the transcription factor SALL1-associated super-enhancer is exclusively activated in microglia, in part through SMAD4-mediated signaling, and that SALL1 subsequently enforces microglia-specific functions of SMAD4.

Bethany R. Fixsen
Claudia Z. Han
Christopher K. Glass
ResearchOpen Access15 Jun 2023
Nature Immunology

Volume: 24, P: 1188-1199
Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung

The lung harbors multiple macrophage subsets that play distinct roles. Sajti and colleagues perform genome-wide epigenetic profiling on sorted populations of lung myeloid cell subsets to determine the effects of genetic background and inflammatory insults on gene expression patterns.

Eniko Sajti
Verena M. Link
Christopher K. Glass
Research20 Jan 2020
Nature Immunology

Volume: 21, P: 221-231
ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge’s disease

Priti Azad
Andrew B. Caldwell
Gabriel G. Haddad
ResearchOpen Access07 Jun 2022
Experimental & Molecular Medicine

Volume: 54, P: 777-787

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