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Showing 1–2 of 2 results
Advanced filters: Author: Nathaniel Braffman Clear advanced filters

  • Natural products discovery remains an ongoing challenge. Now, halide depletion offers a complementary approach to discover natural products whose biosynthesis requires halides, including products of cryptic halogenation. Halide depletion reveals that nostochlorosides, the products of an orphan biosynthetic gene cluster in Nostoc punctiforme, are polymerized by a halide-displacing etherifying enzyme.

    • Nathaniel R. Glasser
    • Dongtao Cui
    • Emily P. Balskus
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 173-182

  • Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a distinct mechanism.

    • James Peek
    • Mirjana Lilic
    • Sean F. Brady
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15