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Showing 1–5 of 5 results
Advanced filters: Author: Neal Paragas Clear advanced filters

  • The current diagnosis of acute kidney injury involves the measurement of renal biomarkers, such as serum creatinine, which provide a crude means of detecting cellular stress and injury. To determine whether Ngal expression provides an alternate renal biomarker capable of detecting the initial phases of renal injury, Paragas et al. have developed an Ngal reporter mouse that offers a noninvasive and real-time method for the continuous and quantitative reporting of cell stress and injury at the injury site.

    • Neal Paragas
    • Andong Qiu
    • Jonathan Barasch
    Research
    Nature Medicine
    Volume: 17, P: 216-222

  • Analysis of bioluminescence images of bacterial distributions in living animals is mostly manual and semiquantitative. Here, the authors present an analysis platform featuring an animal mold, a probabilistic organ atlas, and a mirror gantry to perform automatic in vivo bioluminescence quantification.

    • Alexander D. Klose
    • Neal Paragas
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Miyazaki, Gharib, Hsu et al. use a combined cell-specific luciferase reporter system and chemo-selective substrate to identify mouse tissues at risk of renal injury. The platform can be used to identify cell-specific pathophysiological events and transcriptional changes, finding potential therapeutic targets.

    • Tomoaki Miyazaki
    • Sina A. Gharib
    • Neal Paragas
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-12

  • The lipocalin protein Scn-Ngal is known to bind iron-chelating siderophores, leading to inhibition of bacterial growth. New results reveal that Scn-Ngal, in the absence of bacterial infection, can form a complex with catechol that binds and transports iron in vivo.

    • Guanhu Bao
    • Matthew Clifton
    • Jonathan Barasch
    Research
    Nature Chemical Biology
    Volume: 6, P: 602-609