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Showing 1–2 of 2 results
Advanced filters: Author: Neil C Raffelt Clear advanced filters

  • Granulocyte colony-stimulating factor (G-CSF) is used to accelerate neutrophil engraftment in bone marrow transplant (BMT) recipients to reduce bacterial infections but may also enhance the risk of graft-versus-host disease (GVHD). Morris et al. now show that total body irradiation increases the expression of the G-CSF receptor on recipient dendritic cells, resulting in the activation of donor natural killer T cells and enhanced GVHD when G-CSF is administered shortly after BMT (pages 363–364).

    • Edward S Morris
    • Kelli P A MacDonald
    • Geoffrey R Hill
    Research
    Nature Medicine
    Volume: 15, P: 436-441

  • Graft-versus-host disease (GVHD) can be a life-threatening complication of bone marrow transplantation (BMT). Understanding the mechanisms causing GVHD is important to developing treatments or preventive therapies. In this issue, Koyama et al. report the surprising finding that recipient nonhematopoietic antigen-presenting cells, rather than dendritic cells, are the crucial factor in inducing CD4+ T cell–dependent GVHD and death in mice.

    • Motoko Koyama
    • Rachel D Kuns
    • Geoffrey R Hill
    Research
    Nature Medicine
    Volume: 18, P: 135-142