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Advanced filters: Author: Neil R. Hardingham Clear advanced filters

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, heart and peritoneum of otherwise healthy mice.

Rocío Rojo
Anna Raper
Clare Pridans
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-17
Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

Marion Bonneau
Shane T. O’ Sullivan
J. Kirsty Millar
ResearchOpen Access19 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-16
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

Mandy Johnstone
Navneet A. Vasistha
Siddharthan Chandran
ResearchOpen Access06 Nov 2018
Molecular Psychiatry

Volume: 24, P: 294-311

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