Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Neil Romberg Clear advanced filters

  • Erwin Gelfand, Andrew Snow, Joshua Milner and colleagues identify heterozygous CARD11 mutations associated with severe atopic disease in eight individuals from four families. They further show that the mutant CARD11 proteins exhibit both loss-of-function and dominant-interfering activity and that the cellular defects in patient T cells can be partially rescued by supplementing with glutamine.

    • Chi A Ma
    • Jeffrey R Stinson
    • Joshua D Milner
    Research
    Nature Genetics
    Volume: 49, P: 1192-1201

  • T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the function of key regulatory elements and genes in vitro.

    • Chun Su
    • Matthew E. Johnson
    • Andrew D. Wells
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Richard Lifton, Barbara Kazmierczak and colleagues report the identification of a new enterocolitic and autoinflammatory syndrome, which they find is caused by de novo gain-of-function mutations affecting the inflammasome protein NLRC4. Cells with mutant NLRC4 produce elevated levels of cleaved caspase-1, which leads to cell death by pyroptosis.

    • Neil Romberg
    • Khatoun Al Moussawi
    • Richard P Lifton
    Research
    Nature Genetics
    Volume: 46, P: 1135-1139

  • A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.

    • Theodore L. Roth
    • Cristina Puig-Saus
    • Alexander Marson
    Research
    Nature
    Volume: 559, P: 405-409