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Advanced filters: Author: Nela Zvereva Clear advanced filters

  • Overabundance of the eIF2–GTP–Met-tRNAi translational initiation complex has been linked to malignant transformation. N,N'-diarylurea chemical probes that block ternary complex assembly through heme-regulated inhibitor kinase activation validate translational initiation pathways as a potential anti-cancer targets.

    • Ting Chen
    • Duygu Ozel
    • Bertal H Aktas
    Research
    Nature Chemical Biology
    Volume: 7, P: 610-616