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Building a bigger brain

An innovative approach to analysing the functions and gene-expression profiles of neural stem cells in developing human and mouse brains sheds light on the differences — and similarities — between the two species. See Letter p.264

Forrest O. Gulden
Nenad Šestan
News & Views12 Nov 2014
Nature

Volume: 515, P: 206-207
Recessive LAMC3 mutations cause malformations of occipital cortical development

Murat Gunel and colleagues report the identification of mutations in the laminin γ3 gene that cause complex bilateral occipital cortical gyration abnormalities in humans.

Tanyeri Barak
Kenneth Y Kwan
Murat Günel
Research15 May 2011
Nature Genetics

Volume: 43, P: 590-594
Spatio-temporal transcriptome of the human brain

Hyo Jung Kang
Yuka Imamura Kawasawa
Nenad Šestan
Research26 Oct 2011
Nature

Volume: 478, P: 483-489
Cis-regulatory control of corticospinal system development and evolution

SOX transcription factors converge on a cortex-specific enhancer to regulate the dynamic, cell-type-specific expression of Fezf2, a gene necessary for the formation of corticospinal system.

Sungbo Shim
Kenneth Y. Kwan
Nenad Šestan
Research30 May 2012
Nature

Volume: 486, P: 74-79
Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors

Mladen-Roko Rašin
Valeswara-Rao Gazula
Nenad Šestan
Research24 Jun 2007
Nature Neuroscience

Volume: 10, P: 819-827
Transcriptional landscape of the prenatal human brain

A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.

Jeremy A. Miller
Song-Lin Ding
Ed S. Lein
Research02 Apr 2014
Nature

Volume: 508, P: 199-206
Midline radial glia translocation and corpus callosum formation require FGF signaling

Karen Müller Smith
Yasushi Ohkubo
Flora M Vaccarino
Research21 May 2006
Nature Neuroscience

Volume: 9, P: 787-797
De novo mutations revealed by whole-exome sequencing are strongly associated with autism

Rare de novo single nucleotide variants in brain-expressed genes are found to be associated with autism spectrum disorders and to carry large effects.

Stephan J. Sanders
Michael T. Murtha
Matthew W. State
Research04 Apr 2012
Nature

Volume: 485, P: 237-241
Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

Mapping disease loci that underlie putative Mendelian forms of malformations of cortical development is complicated by genetic heterogeneity, small family sizes and diagnostic classifications that may not reflect molecular pathogenesis. These authors use whole-exome sequencing to identify recessive mutations in WDR62 as the cause of a wide spectrum of severe cerebral cortical malformations. WDR62's nuclear localization to germinal neuroepithelia indicates that cortical malformations can be caused by events during progenitor proliferation and neurogenesis.

Kaya Bilgüvar
Ali Kemal Öztürk
Murat Günel
Research22 Aug 2010
Nature

Volume: 467, P: 207-210
Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans

A Gulhan Ercan-Sencicek
Samira Jambi
Matthew W State
Research30 Apr 2014
European Journal of Human Genetics

Volume: 23, P: 165-172
AgRP neurons control structure and function of the medial prefrontal cortex

Bernardo Stutz
Michael J. Waterson
Tamas L. Horvath
Research29 Jul 2022
Molecular Psychiatry

Volume: 27, P: 3951-3960

Search

Building a bigger brain

Recessive LAMC3 mutations cause malformations of occipital cortical development

Spatio-temporal transcriptome of the human brain

Cis-regulatory control of corticospinal system development and evolution

Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors

Transcriptional landscape of the prenatal human brain

Midline radial glia translocation and corpus callosum formation require FGF signaling

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans

AgRP neurons control structure and function of the medial prefrontal cortex

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