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The authors present a digital camouflage strategy in optical/thermal infrared/terahertz/microwave bands. It mimics plant spectra in optical and creates adaptable patterns in other bands, blending with surroundings to evade multi-spectral detection.

The authors show cryo-electron microscopy structures of the human high-affinity sodium–dicarboxylate cotransporter, responsible for dicarboxylate import into the cell, in complex with various substrates and in different states establish the basis of substrate recognition, differentiation and release, as well as regulation of transport domain movement.

It is generally more difficult to modify the buried interfaces compared to top interfaces in tin-lead perovskite subcells. Here, the authors employ a mercapto-functionalized mesoporous silica layer as a superstructure, realizing maximum efficiency of 29.6% for double-junction tandem solar cells.

Shi, Zhou, Xuan, Jiang et al. identify a population of CD8⁺ T cells that migrate from bone marrow to the small intestine during leukaemogenesis and then traffic back to contribute to anti-leukaemia immune responses during chemotherapy treatment.

Small transporters pose a challenge for cryo-EM structure elucidation. Here, the authors tackled this limitation by rigidly fusing a fiducial marker to a transporter C-terminus, enabling multiple structures to be elucidated from a single sample.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

Semi-aquatic robots rely on surface tension for propulsion, which implies that breaking the water surface is a limitation. Here, the authors developed a soft robot with a superhydrophobic body, achieving high jumping height and take-off velocity.

Efflux pumps confer antibiotic resistance by coupling proton import with drug export. In this work, the authors uncover the proton-coupled transport mechanism for the clinically relevant efflux pump NorA from the pathogenic bacterium S. aureus.

Structures of the human sodium-dependent citrate transporter NaCT in complexes with citrate or a small-molecule inhibitor reveal how the inhibitor—which binds to the same site as citrate—arrests the transport cycle of NaCT.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

The sphingolipid GIPC in the plant cell plasma membrane binds to sodium and triggers calcium influx, thereby triggering responses to excess salt such as efflux of sodium ions from cells.

DASS carboxylate transporters linked to metabolic diseases couple the Na⁺ gradient to nutrient uptake. Here, the authors unravel the structural basis by which Na⁺ binding coordinates substrate interactions, revealing a distinct coupling mechanism.

(Hetero)polyaryl amines are extensively prevalent in pharmaceuticals, fine chemicals, and materials but the intricate and varied nature of their structures severely restricts their synthesis. Here, the authors present a selective multicomponent cycloaromatization of structurally and functionally diverse amine substrates for the general and modular synthesis of (hetero)polyaryl amines through copper(I)-catalysis.

Cryo-EM analysis of the quinolone transporter NorA in complex with synthetic antigen-binding fragments (Fabs) inspired peptide mimics of the Fabs that inhibit methicillin-resistant Staphylococcus aureus in combination with the antibiotic norfloxacin.

Solute transport during rapid and repeated thermal cycles is important in additive manufacturing process. Here, the authors develop a fully-coupled model to rationalise solute transport process, elemental segregation, and non-equilibrium solid/liquid interfacial evolution at sub-grain scale.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Gut microbiota has been reported to influence osteoporosis risk, but the individual species, and underlying mechanisms, remain largely unknown. Here, the authors identify Bacteroides vulgatus and serum valeric acid as potential targets for osteoporosis prevention/treatment.

The efficiency of all-perovskite tandem solar cells is impacted by the nonradiative recombination loss in Sn–Pb mixed narrow bandgap perovskite films. Here, the authors utilize a surface polishing agent with surface passivator to deliver films with a close-to-ideal stoichiometric ratio surface.

Bacterial energy-coupling factor (ECF) transporters mediate ATP-dependent uptake of essential environmental micronutrients. Biochemical and fluorescence analyses now show that ATP binding promotes release of a substrate-capturing subunit that dynamically reassociates with the transmembrane module during the transport cycle.

Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autophagy reduces fibroblast activation and ameliorates fibrotic tissue remodeling.

A swallowable X-ray dosimeter detects the absolute absorbed radiation dose alongside changes in pH and temperature in the gastrointestinal tract of rabbits.

IgA nephropathy is a common cause of glomerulonephritis. The presence of aberrantly galactosylated IgA1 and production of glycan-specific antibodies initiates mesangial deposition of immune complexes and subsequent tubulointerstitial injury. In this Review, Kar Neng Lai summarizes the latest findings in the pathogenesis of IgA nephropathy, including genetic factors and mesangial-derived mediators that lead to podocyte and tubulointerstitial injury via mesangio–podocytic–tubular crosstalk.

Propulsive motion in soft robotic systems requires the power amplification of stored energy. An accumulated strain energy-fracture power-amplification method is used to create light-driven soft robotic systems with a controlled launching ability.

Adjuvant gefitinib improves outcomes in non-small cell lung cancer (NSCLC) patients compared to chemotherapy, but not in all cases. Here, the authors find genomic biomarkers of response to gefitinib in NSCLC patients from the ADJUVANT trial, and propose a score to stratify them by potential benefit from the treatment.

Chen et al. report that the immune modulatory metabolite itaconic acid selectively inhibits the activity of TET DNA dioxygenases to repress the inflammatory responses.

Mesozoic deformation of the North China Craton occurred via lithospheric thickening followed by thinning and extension triggered by flat-slab subduction and rollback, according to four-dimensional mantle flow models of the plate–mantle system.

Existing methods for detecting DNA methylation (5mC) are less accurate and robust. Here, the authors develop a deep learning tool ccsmeth and a Nextflow pipeline ccsmethphase for genome-wide 5mCpG detection and phasing with high accuracy from CCS reads in human.

Astrocytes contribute to autism spectrum disorder (ASD) pathophysiology. Here, the authors show that IP3R2 conditional KO mice show ASD-like behaviours and identify astrocyte-derived ATP as a modulator of these behaviours in mice.

Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT₆R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT_2CR.

The principle of heterosis, whereby a hybrid variety outperforms both parents, is commonly exploited in agriculture to maximize crop yield. Here Huang et al.show that the accumulation of multiple superior alleles in hybrid varieties contributes to hybrid vigour and increased yield in rice.

The dynamic transformation in soft architected materials often brings in unusual properties. Here, Zhang et al. present magneto-elastomers with 3D heterogeneous magnetization profiles encoded by buckling instability to achieve the dynamic regulation.

Cenozoic landscape evolution of southwestern North America remains debated. Here, the authors reconstruct landscape using 4-D numerical models, which can explain extensional collapse and superficial geological record for the Basin and Range Province

Retinitis pigmentosa is the leading cause of inherited blindness worldwide. Here, the authors use exome sequencing to identify mutations in SLC7A14that may be linked to the disease, and provide functional support for the role of this gene in retinal development and visual function in mice and zebrafish.

During mitosis the translocase PICH binds to ultrafine bridges formed from DNA catenanes that are unresolved by topoisomerase II. In this study, the authors show that PICH stimulates toposiomerase II activity and that they cooperate to resolve these structures.