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RNA transcripts serve as a template for double-strand break repair in human cells

DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB repair. This process can lead to intron deletion, resulting in a mutational signature in cancer genomes.

Manisha Jalan
Alessandra Brambati
Agnel Sfeir
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-16
RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability

Collisions of transcription and replication machineries on the same DNA strand threaten genomic stability. Here, the authors show that RAD52 prevents these collisions by regulating R-loop formation and resolution. RAD52 deficiency leads to increased R-loops, exacerbated collisions, DNA damage, and higher mutational burden in tumors.

Manisha Jalan
Aman Sharma
Simon N. Powell
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-17
NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer

The multifunctional NUMB protein negatively regulates the NOTCH signalling pathway, which is deregulated in prostate cancer. The authors detail the complex interactions between NUMB and NOTCH, describing the current targets for therapeutic intervention and the potential use of NUMB profiling in patients with prostate cancer.

Victoria Anastasia Belle
Niamh McDermott
Laure Marignol
Reviews19 Aug 2014
Nature Reviews Urology

Volume: 11, P: 499-507
A 2,000-year Bayesian NAO reconstruction from the Iberian Peninsula

Armand Hernández
Guiomar Sánchez-López
Santiago Giralt
ResearchOpen Access11 Sept 2020
Scientific Reports

Volume: 10, P: 1-15
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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RNA transcripts serve as a template for double-strand break repair in human cells

RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability

NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer

A 2,000-year Bayesian NAO reconstruction from the Iberian Peninsula

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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