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An mRNA vaccine encoding five conserved Group A Streptococcus antigens

There are currently no licensed vaccines to prevent Group A Streptococcus (GAS) infections. In this study, the authors evaluate the immune response and preclinical efficacy of a multicomponent mRNA lipid-nanoparticle vaccine against GAS.

Nichaela Harbison-Price
Ismail Sebina
Mark J. Walker
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection

Stephan Brouwer
Tania Rivera-Hernandez
Mark J. Walker
Amendments and Corrections03 Jul 2023
Nature Reviews Microbiology

Volume: 21, P: 619
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well as cholesterol acquisition.

Andre Mu
William P. Klare
Mark J. Walker
ResearchOpen Access18 Mar 2023
Nature Communications

Volume: 14, P: 1-21
Detection of Streptococcus pyogenes M1_UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

A variant of group A Streptococcus serotype M1 (UK) has been increasingly reported and can be differentiated from the global variant by its overexpression of the superantigen SpeA. Here, Davies et al probe the mechanism behind enhanced SpeA expression and demonstrate that a SNP in the 5’ leader sequence of ssrA is responsible for this virulence phenotype.

Mark R. Davies
Nadia Keller
Mark J. Walker
ResearchOpen Access24 Feb 2023
Nature Communications

Volume: 14, P: 1-12
Pathogenesis, epidemiology and control of Group A Streptococcus infection

In this Review, Brouwer et al. summarize recent developments in our understanding of Group A Streptococcus (GAS), focusing on the epidemiologic and clinical features of GAS infection and the molecular mechanisms associated with GAS virulence and drug resistance.

Stephan Brouwer
Tania Rivera-Hernandez
Mark J. Walker
Reviews09 Mar 2023
Nature Reviews Microbiology

Volume: 21, P: 431-447

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An mRNA vaccine encoding five conserved Group A Streptococcus antigens

Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Detection of Streptococcus pyogenes M1_UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

Pathogenesis, epidemiology and control of Group A Streptococcus infection

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An mRNA vaccine encoding five conserved Group A Streptococcus antigens

Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

Pathogenesis, epidemiology and control of Group A Streptococcus infection

Search

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Detection of Streptococcus pyogenes M1_UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA