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Showing 1–13 of 13 results
Advanced filters: Author: Nicholas J Priebe Clear advanced filters

  • Saccadic eye movements during free viewing exhibit patterns that reflect a strategy to increase neural responses by matching motor behavior with the statistics of the natural world and with the processing limitations of sensory systems.

    • Jason M. Samonds
    • Wilson S. Geisler
    • Nicholas J. Priebe
    Research
    Nature Neuroscience
    Volume: 21, P: 1591-1599

  • Intracellular recordings distinguish between mechanisms that can account for variability in primary visual cortex of alert primates, consistent with a scheme in which spiking is driven by infrequent synchronous events during fixation, with sensory stimulation shifting the cortex to an asynchronous state.

    • Andrew Y. Y. Tan
    • Yuzhi Chen
    • Nicholas J. Priebe
    Research
    Nature
    Volume: 509, P: 226-229

  • It remains unclear how rapid antibiotic switching affects the evolution of antibiotic resistance in individual patients. Here, Chung et al. combine short- and long-read sequencing and resistance phenotyping of 420 serial isolates of Pseudomonas aeruginosa collected from the onset of respiratory infection, and show that rare resistance mutations can increase by nearly 40-fold over 5–12 days in response to antibiotic changes, while mutations conferring resistance to antibiotics not administered diminish and even go to extinction.

    • Hattie Chung
    • Christina Merakou
    • Gregory P. Priebe
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Bipolar disorder (BD) is a severe mood disorder, which has been shown to have a large genetic component. Here the authors identify two previously unreported BD risk loci and provide further insights into the biological mechanisms underlying BD development.

    • Thomas W. Mühleisen
    • Markus Leber
    • Sven Cichon
    Research
    Nature Communications
    Volume: 5, P: 1-8

  • Neurons in the brain's visual cortex receive inputs from thousands of other neurons. But it now emerges that each is strongly connected to only a few others: those most similar to itself. See Letter p.399

    • Benjamin Scholl
    • Nicholas J. Priebe
    News & Views
    Nature
    Volume: 518, P: 306-307

  • A neuron can receive thousands of inputs that, together, tell it when to fire. New techniques can image the activity of many inputs, and shed light on how single neurons perform computations in response.

    • Nicholas J. Priebe
    • David Ferster
    News & Views
    Nature
    Volume: 464, P: 1290-1291

  • The authors measured the variability of neuronal responses across a large number of datasets and cortical areas. They found that variability decreased in response to all stimuli tested, whether the animal was awake, behaving or anesthetized, suggesting that the stabilization of cortex in response to an input is a general cortical property.

    • Mark M Churchland
    • Byron M Yu
    • Krishna V Shenoy
    Research
    Nature Neuroscience
    Volume: 13, P: 369-378

  • Roy Kishony and colleagues sequenced the genomes of 112 Burkholderia dolosa isolates recovered from 14 individuals with cystic fibrosis as part of a retrospective study from a hospital epidemic monitored over the course of 16 years. They tracked recurrent mutations occurring in the bacterial isolates and found that 17 genes showed evidence of parallel adaptive evolution.

    • Tami D Lieberman
    • Jean-Baptiste Michel
    • Roy Kishony
    Research
    Nature Genetics
    Volume: 43, P: 1275-1280

  • The genetics of schizophrenia and other mental disorders are complex and poorly understood, and made even harder to study due to reduced reproduction resulting in negative selection pressure on risk alleles. Two independent large-scale genome wide studies of thousands of patients and controls by two international consortia confirm a previously identified locus, but also reveal novel associations. In this study, de novo (spontaneous) copy number variants are reported on chromosomes 1 and 15.

    • Hreinn Stefansson
    • Dan Rujescu
    • Kari Stefansson
    Research
    Nature
    Volume: 455, P: 232-236

  • Sub-additive responses to simultaneously presented stimuli and quenching of variability in responses to repeated presentations of a stimulus are characteristics of neurons in the primary visual cortex. In this Perspective, Goris et al. argue that these phenomena often co-occur and may have common mechanistic and computational origins.

    • Robbe L. T. Goris
    • Ruben Coen-Cagli
    • Máté Lengyel
    Reviews
    Nature Reviews Neuroscience
    Volume: 25, P: 237-252