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Showing 51–86 of 86 results

Advanced filters: Author: Nicholas J. Maurice Clear advanced filters

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

Qiao Fan et al. report a genome-wide association analysis of corneal curvature—an important measurement for identifying vision problems, such as myopia—in more than 45,000 individuals of either European or Asian ancestry. They identify 47 loci, 26 of which are novel, with some showing population-specific effects and pleiotropic effects on eye elongation and myopia.

Qiao Fan
Alfred Pozarickij
Ching-Yu Cheng
ResearchOpen Access19 Mar 2020
Communications Biology

Volume: 3, P: 1-14
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies

A mass spectrometric analysis of plasma tau species identifies phosphorylated tau peptides p-tau217, p-tau231 and p-tau205 with distinct correlations with amyloid and tau pathologies and emergences along the AD continuum.

Laia Montoliu-Gaya
Andréa L. Benedet
Kaj Blennow
ResearchOpen Access27 Apr 2023
Nature Aging

Volume: 3, P: 661-669
Author Correction: A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

Ke Wang
Amit Goldenberg
Hannah Moshontz
Amendments and Corrections24 Aug 2022
Nature Human Behaviour

Volume: 6, P: 1318-1319
Publisher Correction: Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample

Bence Bago
Marton Kovacs
Balazs Aczel
Amendments and Corrections06 Jun 2022
Nature Human Behaviour

Volume: 6, P: 897-898
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium

Qiao Fan
Xiaobo Guo
Zoran Vatavuk
ResearchOpen Access13 May 2016
Scientific Reports

Volume: 6, P: 1-14
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease

Personalized brain activity models in Alzheimer’s disease detect synergistic amyloid-β and tau impacts on neuronal excitability values, which significantly predict brain atrophy, p-tau217 plasma concentrations, and cognitive deterioration.

Lazaro M. Sanchez-Rodriguez
Gleb Bezgin
Yasser Iturria-Medina
ResearchOpen Access04 May 2024
Communications Biology

Volume: 7, P: 1-13
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Ammar Al-Chalabi, Jan Veldink and colleagues perform a genome-wide association study for amyotrophic lateral sclerosis (ALS) in 15,156 cases and 26,242 controls. They identify three new genome-wide-significant variants and establish ALS as a complex trait with a polygenic architecture, but with a distinct and important role for low-frequency variants.

Wouter van Rheenen
Aleksey Shatunov
Jan H Veldink
Research25 Jul 2016
Nature Genetics

Volume: 48, P: 1043-1048
Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders

Filippo Erli
Alish B. Palmos
Deepak P. Srivastava
ResearchOpen Access21 Jan 2020
Translational Psychiatry

Volume: 10, P: 1-14
Purcell-enhanced single photons at telecom wavelengths from a quantum dot in a photonic crystal cavity

Catherine L. Phillips
Alistair J. Brash
A. Mark Fox
ResearchOpen Access23 Feb 2024
Scientific Reports

Volume: 14, P: 1-9
Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial

Morgane Linard
Isabelle Garrigue
Catherine Helmer
ResearchOpen Access18 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study

Eleanor L. Watts
Tomas I. Gonzales
Soren Brage
ResearchOpen Access06 Dec 2023
British Journal of Cancer

Volume: 130, P: 114-124
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
Amendments and CorrectionsOpen Access31 Jan 2022
Nature Genetics

Volume: 54, P: 361
Cell adhesion molecule CD44 is dispensable for reactive astrocyte activation during prion disease

Barry M. Bradford
Lauryn Walmsley-Rowe
Neil A. Mabbott
ResearchOpen Access14 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction

Nicholas M. Maurice
Brahmchetna Bedi
Ruxana T. Sadikot
ResearchOpen Access15 Aug 2019
Scientific Reports

Volume: 9, P: 1-15
Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes

Michael Pudjihartono
Nicholas Pudjihartono
William Schierding
ResearchOpen Access04 Oct 2024
British Journal of Cancer

Volume: 131, P: 1644-1655
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

Recent technological advances have enabled the detection of specific forms of phosphorylated tau in blood. Here, the authors summarize the performance of blood phosphorylated tau biomarkers in the context of Alzheimer disease and highlight related ethical, analytical and clinical challenges.

Thomas K. Karikari
Nicholas J. Ashton
Henrik Zetterberg
Reviews18 May 2022
Nature Reviews Neurology

Volume: 18, P: 400-418
An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

Most research into blood-based biomarkers for neurodegenerative disorders has so far focused on Alzheimer disease. In this Review, Aarsland and colleagues give an overview of the current status of blood-based biomarkers for the non-Alzheimer disease neurodegenerative disorders.

Nicholas J. Ashton
Abdul Hye
Dag Aarsland
Reviews22 Apr 2020
Nature Reviews Neurology

Volume: 16, P: 265-284
Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA

Fiona S Togneri
Douglas G Ward
Richard T Bryan
ResearchOpen Access13 Jan 2016
European Journal of Human Genetics

Volume: 24, P: 1167-1174
Layer-specific lipid signatures in the human subventricular zone demonstrated by imaging mass spectrometry

Mandana Hunter
Nicholas J. Demarais
Maurice A. Curtis
ResearchOpen Access07 Feb 2018
Scientific Reports

Volume: 8, P: 1-12
The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study): a UK national observational cohort study

Lewis A. Hall
Siobhan C. McKay
Melissa Zhao
ResearchOpen Access23 Mar 2023
British Journal of Cancer

Volume: 128, P: 1922-1932
Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial

Sarah E. Herniman
Stephen J. Wood
Rachel Upthegrove
ResearchOpen Access18 Sept 2023
Translational Psychiatry

Volume: 13, P: 1-10
Characterisation of a synthetic Archeal membrane reveals a possible new adaptation route to extreme conditions

By studying the properties of a synthetic membrane mimicking an archaeal membrane and containing the apolar polyisoprenoid squalane, Salvador-Castell et al. show that lipid bilayer stability and functionality are shifted to higher temperatures under high pressure. These findings support the view that apolar lipids may constitute an adaptative route to high-temperature tolerance in archaeal hyperthermophiles.

Marta Salvador-Castell
Maksym Golub
Philippe M. Oger
ResearchOpen Access02 Jun 2021
Communications Biology

Volume: 4, P: 1-13
Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau

Maxime Van Egroo
Joost M. Riphagen
Heidi I. L. Jacobs
ResearchOpen Access05 Apr 2023
Molecular Psychiatry

Volume: 28, P: 2412-2422
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78–94

Malgorzata M. Michalowska
Karl Herholz
Stephen F. Carter
ResearchOpen Access20 Jul 2022
Molecular Psychiatry

Volume: 27, P: 4335-4342
Rare variant analyses across multiethnic cohorts identify novel genes for refractive error

A multi-ethnic meta-analysis of exome array data from over 27,000 participants identifies several rare variants that could contribute to risk of ocular refractive error.

Anthony M. Musolf
Annechien E. G. Haarman
Joan E. Bailey-Wilson
ResearchOpen Access03 Jan 2023
Communications Biology

Volume: 6, P: 1-17
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum

Meenu Rohini Rajan
Matus Sotak
Emma Börgeson
ResearchOpen Access28 Oct 2019
Scientific Reports

Volume: 9, P: 1-14
Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer

Ben Lawrence
Cherie Blenkiron
Cristin Print
ResearchOpen Access20 Jul 2018
npj Genomic Medicine

Volume: 3, P: 1-12
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study

Antoinette O’Connor
Thomas K. Karikari
Nick C. Fox
Research14 Jul 2020
Molecular Psychiatry

Volume: 26, P: 5967-5976
Automated detection and enumeration of marine wildlife using unmanned aircraft systems (UAS) and thermal imagery

A. C. Seymour
J. Dale
D. W. Johnston
ResearchOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Genomic epidemiology of Shigella in the United Kingdom shows transmission of pathogen sublineages and determinants of antimicrobial resistance

Kate S. Baker
Timothy J. Dallman
Nicholas Thomson
ResearchOpen Access09 May 2018
Scientific Reports

Volume: 8, P: 1-8
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative

Thomas K. Karikari
Andréa L. Benedet
Henrik Zetterberg
Research26 Oct 2020
Molecular Psychiatry

Volume: 26, P: 429-442

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