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Showing 1–21 of 21 results
Advanced filters: Author: Nicholas J. Talley Clear advanced filters

  • IBS is a common disorder that can have an enormous negative effect on patients and society as a whole; however, many patients do not achieve adequate symptom relief with the currently available therapies. In this Review, Magnus Halland and Nicholas Talley discuss the latest treatments for IBS, including novel nonpharmacological and pharmacological approaches.

    • Magnus Halland
    • Nicholas J. Talley
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 13-23

  • This Review considers the optimal approach to assessing the common medical problem of noncardiac chest pain, for which the appropriate application of investigations is controversial. In addition to musculoskeletal and psychiatric investigations, gastroesophageal investigations include esophagogastroduodenoscopy, radiological assessment, ambulatory esophageal pH monitoring, esophageal manometry, provocative tests, and a proton pump inhibitor test.

    • Guy D Eslick
    • David S Coulshed
    • Nicholas J Talley
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 2, P: 463-472

  • Dyspepsia is remarkably common. Of those individuals with dyspepsia who present for care, perhaps 10% are referred because their symptoms remain refractory and troublesome. Many gastroenterologists seem to feel somewhat at a loss in this situation; however, there are sensible management options to consider. This Review considers the testing and treatment alternatives, and discusses what can be done for the difficult-to treat dyspeptic patient.

    • Nicholas J Talley
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 4, P: 35-42

  • The choice of therapy for patients with irritable bowel syndrome (IBS) has been based on the predominant bowel symptom; however, it has proven difficult to identify any optimal single pharmacological therapeutic targets. This Review summarizes current and future therapeutic strategies for the treatment of IBS on the basis of putative pathophysiological models.

    • Filippo Cremonini
    • Nicholas J Talley
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 2, P: 82-88

  • Eosinophils are potent innate immune cells that are numerous in the gastrointestinal tract in health and disease. This Review discusses the role of eosinophils in the pathogenesis of numerous disorders of the gastrointestinal tract, including primary eosinophilic gastrointestinal disorders, common functional conditions (such as dyspepsia), and gastrointestinal disorders in patients with allergic disease.

    • Nicholas Powell
    • Marjorie M. Walker
    • Nicholas J. Talley
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 7, P: 146-156

  • IBS is a chronic, fluctuating disorder that continues to be the subject of considerable research. 2010 saw some key advances across all aspects of IBS, including further advances in our understanding of the pathophysiology, diagnosis and treatment of this condition.

    • Alexander C. Ford
    • Nicholas J. Talley
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 8, P: 76-78

  • In the past decade we have witnessed an explosion in the quantity and quality of research in the functional gastrointestinal disorders. I discuss 10 top original research papers that, unless recent, have been highly cited, published in a high-impact journal and have probably shifted thinking in the field.

    • Nicholas J. Talley
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 649-650

  • The Rome III consensus has divided functional dyspepsia into two subgroups; postprandial distress syndrome, characterized by postprandial fullness and early satiation, and epigastric pain syndrome, characterized by epigastric pain or burning. This Review describes the symptoms of functional dyspepsia and discusses the evidence to support the two subgroups.

    • Jan Tack
    • Nicholas J. Talley
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 134-141

  • The development of effective acid-suppression therapy has revolutionized the treatment of acid-related diseases. This Review provides an update on the status of acid-suppression therapy and includes discussion of the efficacy and safety of available agents, novel agents in development, risks of acid suppression, and directions for future research.

    • Kenneth R. DeVault
    • Nicholas J. Talley
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 6, P: 524-532

  • Bidirectional gut–brain communications are proving key to both gastrointestinal and neurological diseases. This Review explores the role of the mucosal immune system as gatekeeper and master regulator of these brain–gut and gut–brain communications.

    • Nick Powell
    • Marjorie M. Walker
    • Nicholas J. Talley
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 143-159

  • Functional dyspepsia is a functional gastrointestinal disorder characterized by discomfort or pain in the upper abdomen (generally associated with food intake) with no apparent underlying organic cause. The three subtypes of functional dyspepsia are postprandial distress syndrome, epigastric pain syndrome and a subtype with mixed features.

    • Paul Enck
    • Fernando Azpiroz
    • Nicholas J. Talley
    Reviews
    Nature Reviews Disease Primers
    Volume: 3, P: 1-20