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Showing 1–5 of 5 results
Advanced filters: Author: Nicholas Jendzjowsky Clear advanced filters

  • Sensory neurons may regulate innate immune cells, but their roles in humoral immunity is still unclear. Here the authors show that bacterial infection and asthma induction induce sensory neuron production of distinct neurotransmitters to dampen B cell responses but differentially target IgG and IgE, respectively, to specifically modulate the symptoms.

    • Diane Aguilar
    • Fengli Zhu
    • Nicholas Jendzjowsky
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Proliferative and effector functions of T cells are determined by T cell receptor signalling and modulated by activator and inhibitory co-receptors. Authors report here that the G-protein-coupled receptor GPR171 functions as a co-inhibitor of T cell signalling and might serve as a target for cancer immunotherapy.

    • Yuki Fujiwara
    • Robert J. Torphy
    • Yuwen Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The immunomodulatory role of commensal gut fungi and interactions with bacteria remain unclear. Here, using germ-free mice colonized with defined species of bacteria and fungi, the authors find that fungal colonization induces changes in bacterial microbiome ecology while having an independent effect on innate and adaptive immunity in mice.

    • Erik van Tilburg Bernardes
    • Veronika Kuchařová Pettersen
    • Marie-Claire Arrieta
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 and LPA-specific receptor antagonists ameliorate acute bronchoconstriction.

    • Nicholas G. Jendzjowsky
    • Arijit Roy
    • Richard J. A. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15