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Showing 1–3 of 3 results
Advanced filters: Author: Nicholas Khuu Clear advanced filters

  • In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tumours and cell lines and identify a class of ‘Amplification-Related Gain Of Sensitivity’ (ARGOS) genes, with potential therapeutic applications.

    • Veronica Rendo
    • Michael Schubert
    • Floris Foijer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • The development of single cell RNA sequencing technologies has been instrumental in advancing our understanding of tissue biology. Here, MacParland et al. performed single cell RNA sequencing of human liver samples, and identify distinct populations of intrahepatic macrophages that may play specific roles in liver disease.

    • Sonya A. MacParland
    • Jeff C. Liu
    • Ian D. McGilvray
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-21