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Advanced filters: Author: Nicholas M. Girardi Clear advanced filters
  • Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and a first-in-class VCPIP1 probe with nanomolar potency.

    • Wai Cheung Chan
    • Xiaoxi Liu
    • Sara J. Buhrlage
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13