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Showing 1–5 of 5 results
Advanced filters: Author: Nicholas Propson Clear advanced filters

  • The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

    • Xiaofei Gao
    • Xing-jun Chen
    • Woo-ping Ge
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.

    • Bettina van Lengerich
    • Lihong Zhan
    • Kathryn M. Monroe
    ResearchOpen Access
    Nature Neuroscience
    Volume: 26, P: 416-429

  • A defined and simplified culture system for the derivation and growth of human induced pluripotent stem cells is reported. It permits increased efficiency of human reprogramming with an episomal approach. Also in this issue, Okita et al. describe methods for more efficient episomal reprogramming of human cells.

    • Guokai Chen
    • Daniel R Gulbranson
    • James A Thomson
    Research
    Nature Methods
    Volume: 8, P: 424-429

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330