Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–13 of 13 results
Advanced filters: Author: Nicholas V. Hud Clear advanced filters

  • Translational regulation of isoforms in the developing nervous system is not well understood. Here, the authors report translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex and show the neurodevelopmental risk of post-transcriptional dysregulation.

    • Tatiana Popovitchenko
    • Yongkyu Park
    • Mladen-Roko Rasin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-21

  • Removing Mg2+ from RNA and replacing it with Fe2+ confers on some RNAs the ability to catalyse single-electron transfer. Here, it is hypothesized that Fe2+ was an RNA cofactor on the early Earth, when iron was benign and abundant, and was replaced by Mg2+ during a period known as the great oxidation, brought on by photosynthesis.

    • Chiaolong Hsiao
    • I-Chun Chou
    • Loren Dean Williams
    Research
    Nature Chemistry
    Volume: 5, P: 525-528

  • Neighborhood disadvantage and capacity to socially distance have been discussed as factors involved in COVID-19 disparities. Here, the authors develop an inequity index on zip code-level infections, and examine differences in neighborhood utilization of subways in New York City.

    • Daniel Carrión
    • Elena Colicino
    • Allan C. Just
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • One of the early processes enabling the origins of life is thought to be the condensation of building blocks into oligomers and polymers. In this article, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures and various pH, suggesting they could have formed on early prebiotic Earth.

    • Moran Frenkel-Pinter
    • Marcos Bouza
    • Aikomari Guzman-Martinez
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • AUF1 is an RNA-binding protein believed to function mostly by regulating the decay of its target transcripts. Here, Yoon et al.systematically identify the targets of AUF1 and provide insights into how AUF1 functions to regulate various cellular processes by enhancing the decay, stability or translation of specific RNAs.

    • Je-Hyun Yoon
    • Supriyo De
    • Myriam Gorospe
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • Overexpression of all 29 human transcripts of a region of the 16p11.2 chromosome in zebrafish embryos identifies KCTD13 as the message inducing the microcephaly phenotype associated with 16p11.2 duplication, whereas its suppression yields the macrocephalic phenotype associated with the reciprocal deletion, suggesting that KCTD13 is a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 copy number variants.

    • Christelle Golzio
    • Jason Willer
    • Nicholas Katsanis
    Research
    Nature
    Volume: 485, P: 363-367

  • One of the questions for prebiotic chemistry is the formation of complementary base pairing systems. Here, the authors show that plausible two prebiotic heterocycles can form glycosidic bonds with ribose in water and that these spontaneously base-pair in aqueous solution.

    • Brian J. Cafferty
    • David M. Fialho
    • Nicholas V. Hud
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • An unanswered question in the RNA world scenario is how sequence information could be transferred during replication of duplex RNA. Without the aid of sophisticated enzymes, strand reannealing occurs more quickly than template-directed synthesis. Now, a plausible prebiotic solution to this problem is presented, in which a viscous solvent enables information transfer from a gene-length double-stranded template.

    • Christine He
    • Isaac Gállego
    • Nicholas V. Hud
    Research
    Nature Chemistry
    Volume: 9, P: 318-324

  • Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support for the co-evolution of these molecules.

    • Moran Frenkel-Pinter
    • Jay W. Haynes
    • Luke J. Leman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14