Nature Search

Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

Daniel L. Burgess
David C. Kohrman
Miriam H. Meisler
Research01 Aug 1995
Nature Genetics

Volume: 10, P: 461-465
Adaptive foraging behaviours in the Horn of Africa during Toba supereruption

The archaeological site Shinfa-Metema 1 in the lowlands of northwest Ethiopia provides early evidence of intensive riverine-based foraging aided by the likely adoption of the bow and arrow.

John Kappelman
Lawrence C. Todd
Sierra Yanny
Research20 Mar 2024
Nature

Volume: 628, P: 365-372
Correction: Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

Natalie D Shaw
Harrison Brand
Michael E Talkowski
Amendments and Corrections26 May 2017
Nature Genetics

Volume: 49, P: 969
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

The relationship between lipid dyshomeostasis and tau pathology in FTLD and AD remains unclear. Here, the authors demonstrate that GRAMD1B contributes to lipid dyshomeostasis, autophagy impairment, and tau hyperphosphorylation in neurons.

Diana Acosta Ingram
Emir Turkes
Hongjun Fu
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-24
Developmental origins of central norepinephrine neuron diversity

The authors study the lineal origins of norepinephrine (NE) neurons in the mouse hindbrain. They identify four genetically separable subpopulations of NE neurons, each with distinct anatomical location, axonal morphology and pattern of efferent projections. One unexpected finding is a projection to the prefrontal cortex that originates from outside the locus coeruleus.

Sabrina D Robertson
Nicholas W Plummer
Patricia Jensen
Research14 Jul 2013
Nature Neuroscience

Volume: 16, P: 1016-1023
A global horizon scan of the future impacts of robotics and autonomous systems on urban ecosystems

The future challenges and potential opportunities of robotics and autonomous systems in urban ecosystems, and how they may impact biodiversity, are explored and prioritized via a global horizon scan of 170 experts.

Mark A. Goddard
Zoe G. Davies
Martin Dallimer
Research04 Jan 2021
Nature Ecology & Evolution

Volume: 5, P: 219-230
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

Michael Talkowski, David FitzPatrick, Erica Davis and colleagues report rare inherited or de novo missense variants in SMCHD1 in arhinia patients. Some of the same mutations in SMCHD1 are known to cause a phenotypically distinct muscular dystrophy disorder, FSHD2, and the distinct clinical features of the two disorders suggests that additional genes interact with SMCHD1 to cause arhinia.

Natalie D Shaw
Harrison Brand
Michael E Talkowski
Research09 Jan 2017
Nature Genetics

Volume: 49, P: 238-248
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Crystal structures of hGPR40, a target for treatment of type 2 diabetes, bound to a partial and an allosteric agonist explain the binding cooperativity between these ligands and present new opportunities for structure-guided drug design.

Jun Lu
Noel Byrne
Stephen M Soisson
Research05 Jun 2017
Nature Structural & Molecular Biology

Volume: 24, P: 570-577
Using DNA sequencing data to quantify T cell fraction and therapy response

A robust, cost-effective technique based on whole-exome sequencing data can be used to characterize immune infiltrates, relate the extent of these infiltrates to somatic changes in tumours, and enables prediction of tumour responses to immune checkpoint inhibition therapy.

Robert Bentham
Kevin Litchfield
Nicholas McGranahan
Research08 Sept 2021
Nature

Volume: 597, P: 555-560
A subset of noradrenergic (NE) neurons defined by developmental expression of Hoxb1 have a distinct role in attenuating the behavioral response to acute stress

Yu-Wei Chen
Manasmita Das
Patricia Jensen
Research17 Apr 2019
Molecular Psychiatry

Volume: 24, P: 625
Martensite decomposition during rapid heating of Ti-6Al-4V studied via in situ synchrotron X-ray diffraction

Martensite in Ti-6Al-4V is known to decompose under heating. This study employs rapid laser heating in situ in a synchrotron to study changes in the diffraction profiles during the martensite decomposition process.

Seunghee A. Oh
Joseph W. Aroh
Anthony D. Rollett
ResearchOpen Access23 Apr 2024
Communications Materials

Volume: 5, P: 1-10
Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses

Yu-Wei Chen
Manasmita Das
Patricia Jensen
Research13 Sept 2018
Molecular Psychiatry

Volume: 24, P: 710-725

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Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

Adaptive foraging behaviours in the Horn of Africa during Toba supereruption

Correction: Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

Developmental origins of central norepinephrine neuron diversity

A global horizon scan of the future impacts of robotics and autonomous systems on urban ecosystems

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Using DNA sequencing data to quantify T cell fraction and therapy response

A subset of noradrenergic (NE) neurons defined by developmental expression of Hoxb1 have a distinct role in attenuating the behavioral response to acute stress

Martensite decomposition during rapid heating of Ti-6Al-4V studied via in situ synchrotron X-ray diffraction

Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses

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